MeSH Browser

MeSH Heading: Leucovorin
Tree Number(s): D03.633.100.733.631.400.800.350.450; D08.211.840.300.500
Unique ID: D002955
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002955
Annotation: deficiency: coordinate LEUCOVORIN /‌defic (IM) with FOLIC ACID DEFICIENCY (IM)
Scope Note: The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
Entry Term(s): 5-Formyltetrahydrofolate; 5-Formyltetrahydropteroylglutamate; Calcium Folinate; Calcium Leucovorin; Citrovorum Factor; Folinic Acid; Folinic Acid-SF; Leucovorin, (D)-Isomer; Leucovorin, (DL)-Isomer; Leucovorin, (R)-Isomer; Leucovorin, Calcium (1:1) Salt; Leucovorin, Calcium (1:1) Salt, (DL)-Isomer; Leucovorin, Calcium (1:1) Salt, Pentahydrate; Leucovorin, Monosodium Salt; Leukovorin; Leukovorum; N(5)-Formyltetrahydrofolate; Wellcovorin
Pharm Action: Antidotes
Vitamin B Complex
Registry Numbers: Q573I9DVLP; RPR1R4C0P4; 0; 1492-18-8; 22350-60-3; 42476-21-1; 54353-24-1; 6035-45-6; 67005-79-2; 73951-54-9
Related Numbers: 1492-18-8; 22350-60-3; 42476-21-1; 54353-24-1; 58-05-9; 6035-45-6; 67005-79-2; 73951-54-9; RPR1R4C0P4
CAS Type 1 Name: L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
Public MeSH Note: 90; was CITROVORUM FACTOR 1964-89
Online Note: use LEUCOVORIN to search CITROVORUM FACTOR 1966-89
History Note: 90; was CITROVORUM FACTOR 1964-89
Date Established: 1990/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Heterocyclic Compounds [D03]
- Heterocyclic Compounds, Fused-Ring [D03.633]
  - Heterocyclic Compounds, 2-Ring [D03.633.100]
    - Pteridines [D03.633.100.733]
      - Pterins [D03.633.100.733.631]
        
        Folic Acid [D03.633.100.733.631.400]
        
        Tetrahydrofolates [D03.633.100.733.631.400.800]
        
        Formyltetrahydrofolates [D03.633.100.733.631.400.800.350]
        
        Leucovorin [D03.633.100.733.631.400.800.350.450]
        
        Levoleucovorin [D03.633.100.733.631.400.800.350.450.500]

Enzymes and Coenzymes [D08]
- Coenzymes [D08.211]
  - Tetrahydrofolates [D08.211.840]
    - Formyltetrahydrofolates [D08.211.840.300]
      - Leucovorin [D08.211.840.300.500]

Leucovorin Preferred

Concept UI: M0004519
Registry Numbers: Q573I9DVLP
Related Numbers: 1492-18-8; 22350-60-3; 42476-21-1; 54353-24-1; 58-05-9; 6035-45-6; 67005-79-2; 73951-54-9; RPR1R4C0P4
Scope Note: The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
Terms: Leucovorin Preferred Term
Term UI T008548
Date01/01/1999
LexicalTag NON
ThesaurusID; Folinic Acid
Term UI T008546
Date03/29/1974
LexicalTag NON
ThesaurusID; Folinic Acid-SF
Term UI T008547
Date04/24/1989
LexicalTag NON
ThesaurusID NLM (1990); Leukovorum
Term UI T008549
Date10/07/1986
LexicalTag NON
ThesaurusID UNK (19XX); Leukovorin
Term UI T008550
Date10/09/1986
LexicalTag NON
ThesaurusID UNK (19XX)

Citrovorum Factor Narrower

N(5)-Formyltetrahydrofolate Narrower

Leucovorin, Calcium (1:1) Salt Narrower

Leucovorin, (DL)-Isomer Narrower

Leucovorin, Monosodium Salt Narrower

Leucovorin, (D)-Isomer Narrower

Leucovorin, Calcium (1:1) Salt, Pentahydrate Narrower

Leucovorin, Calcium (1:1) Salt, (DL)-Isomer Narrower

Leucovorin, (R)-Isomer Narrower

Wellcovorin Narrower

Leucovorin MeSH Descriptor Data 2025