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Leflunomide MeSH Descriptor Data 2022


MeSH Heading
Leflunomide
Tree Number(s)
D03.383.129.385.475
Unique ID
D000077339
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077339
Scope Note
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
Entry Term(s)
Arava
HWA 486
HWA-486
N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
SU101
Pharm Action
Enzyme Inhibitors
Immunosuppressive Agents
Registry Number
G162GK9U4W
Related Numbers
75706-12-6
CAS Type 1 Name
4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-
Public MeSH Note
2019; LEFLUNOMIDE was indexed under ISOXAZOLES 1991-2018; and under OXAZOLES 1985-1990
History Note
2019 (1985)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/02/27
Leflunomide Preferred
HWA 486 Narrower
SU101 Narrower
Arava Narrower
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