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Proteolysis Targeting Chimera MeSH Descriptor Data 2024


MeSH Heading
Proteolysis Targeting Chimera
Tree Number(s)
D27.720.470.410.210.500
Unique ID
D000094243
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000094243
Scope Note
Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.
Entry Term(s)
Cereblon-Based Small-Molecule Compounds
IAP-Based PROTACs
MDM2 Protein-Based PROTACs
PROTAC Proteolysis Targeting Chimera
PROTACs
Phospho-Dependent PROTACs
PhosphoPROTACs
Proteolysis Targeting Chimeras
VHL-Based PROTACs
Previous Indexing
Proteolysis (2015-2022)
Public MeSH Note
2023
History Note
2023
Date Established
2023/01/01
Date of Entry
2022/07/08
Revision Date
2023/04/05
Proteolysis Targeting Chimera Preferred
Phospho-Dependent PROTACs Narrower
Cereblon-Based Small-Molecule Compounds Narrower
VHL-Based PROTACs Narrower
MDM2 Protein-Based PROTACs Narrower
IAP-Based PROTACs Narrower
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