MeSH Browser

MeSH Heading: Nudix Hydrolases
Tree Number(s): D08.811.277.040.600.600
Unique ID: D000096964
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000096964
Scope Note: A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder.
Entry Term(s): Nucleoside Diphosphates-Linked to Moiety-X Hydrolases; Nudix Hydrolase; Nudix Proteins
Registry Number: EC 3.6.1.-
Public MeSH Note: 2024; see under PYROPHOSPHATASES 1998-2023
History Note: 2024
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/06/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000762793
Registry Number: EC 3.6.1.-
Scope Note: A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder.
Terms: Nudix Hydrolases Preferred Term
Term UI T001133022
Date02/18/2023
LexicalTag NON
ThesaurusID NLM (2024); Nudix Proteins
Term UI T001133020
Date02/18/2023
LexicalTag NON
ThesaurusID NLM (2024); Nucleoside Diphosphates-Linked to Moiety-X Hydrolases
Term UI T001133065
Date02/21/2023
LexicalTag NON
ThesaurusID NLM (2024); Nudix Hydrolase
Term UI T001133021
Date02/18/2023
LexicalTag NON
ThesaurusID NLM (2024)

Nudix Hydrolases MeSH Descriptor Data 2024