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beta-N-Acetylhexosaminidases MeSH Descriptor Data 2022


MeSH Heading
beta-N-Acetylhexosaminidases
Tree Number(s)
D08.811.277.450.483.180
Unique ID
D001619
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D001619
Annotation
do not confuse with ACETYLGLUCOSAMINIDASE; /‌defic: consider also TAY SACHS DISEASE and SANDHOFF DISEASE
Scope Note
A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
Entry Term(s)
N-Acetyl-beta-D-hexosaminidase
beta-Hexosaminidase
beta-N-Acetyl-D-hexosaminidase
beta-N-Acetyl-hexosaminidase
beta-N-Acetylhexosaminidase
Registry Number
EC 3.2.1.52
CAS Type 1 Name
beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase
Previous Indexing
Glycoside Hydrolases (1966-1970)
Hexosaminidases (1971-1986)
See Also
Sandhoff Disease
Tay-Sachs Disease
Public MeSH Note
2008; see BETA-N-ACETYL-D-HEXOSAMINIDASE 1988-2007
History Note
2008(1988)
Date Established
1987/01/01
Date of Entry
1986/06/02
Revision Date
2007/07/09
beta-N-Acetylhexosaminidases Preferred
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