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C-Peptide MeSH Descriptor Data 2024


MeSH Heading
C-Peptide
Tree Number(s)
D06.472.699.587.200.500.250
D12.644.548.586.200.500.250
Unique ID
D002096
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D002096
Annotation
from proinsulin only: not for peptide fragments from other proteins ( = PEPTIDE FRAGMENTS)
Scope Note
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
Entry Term(s)
C-Peptide, Proinsulin
Connecting Peptide
Proinsulin C-Peptide
NLM Classification #
WK 802
Previous Indexing
Peptides (1973-1976)
Proinsulin (1975-1976)
Public MeSH Note
84; was see under PEPTIDES 1977-83
History Note
84(77); was see under PEPTIDES 1977-83
Date Established
1984/01/01
Date of Entry
1976/04/16
Revision Date
2011/06/24
C-Peptide Preferred
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