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Major Depressive Disorder MeSH Descriptor Data 2026


MeSH Heading
Major Depressive Disorder
Tree Number(s)
F03.600.300.375
Unique ID
D003865
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D003865
Scope Note
Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every day; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
Entry Version
MAJOR DEPRESSIVE DIS
Entry Term(s)
Clinical Depression
Depression, Involutional
Depressive Disorder, Major
Major Depression Disorder
Melancholia, Involutional
Paraphrenia, Involutional
Psychosis, Involutional
NLM Classification #
WM 171.5
Public MeSH Note
81; was PSYCHOSES, INVOLUTIONAL 1963-80
Online Note
use DEPRESSION, INVOLUTIONAL to search PSYCHOSES, INVOLUTIONAL & MELANCHOLIA, INVOLUTIONAL 1966-80
History Note
81; was PSYCHOSES, INVOLUTIONAL 1963-80; MELANCHOLIA, INVOLUTIONAL was see under PSYCHOSES, INVOLUTIONAL 1963-78
Date Introduced
1981/01/01
Last Updated
2025/12/02
Major Depressive Disorder Preferred
Depression, Involutional Related
Psychosis, Involutional Related
Paraphrenia, Involutional Narrower
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