MeSH Browser

MeSH Heading: DNA, Superhelical
Tree Number(s): D13.444.308.283.250; G02.111.570.820.486.212.250; G05.360.580.156.250
Unique ID: D004278
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004278
Annotation: IM; /‌drug eff /‌ultrastruct permitted
Scope Note: Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.
Entry Term(s): DNA, Supercoiled; DNA, Supertwisted
Previous Indexing: DNA (1966-1977); DNA, Circular (1973-1977)
Public MeSH Note: 78
History Note: 78
Date Established: 1978/01/01
Date of Entry: 1977/05/17
Revision Date: 2015/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

DNA, Superhelical MeSH Descriptor Data 2024