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DNA, Circular MeSH Descriptor Data 2023


MeSH Heading
DNA, Circular
Tree Number(s)
D13.444.308.283
G02.111.570.820.486.212
G05.360.580.156
Unique ID
D004270
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D004270
Annotation
IM; /‌drug eff /‌ultrastruct permitted
Scope Note
Any of the covalently closed DNA molecules found in bacteria, many viruses, mitochondria, plastids, and plasmids. Small, polydisperse circular DNA's have also been observed in a number of eukaryotic organisms and are suggested to have homology with chromosomal DNA and the capacity to be inserted into, and excised from, chromosomal DNA. It is a fragment of DNA formed by a process of looping out and deletion, containing a constant region of the mu heavy chain and the 3'-part of the mu switch region. Circular DNA is a normal product of rearrangement among gene segments encoding the variable regions of immunoglobulin light and heavy chains, as well as the T-cell receptor. (Riger et al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992)
Entry Term(s)
Circular DNA
Registry Number
0
Previous Indexing
DNA (1966-1972)
Public MeSH Note
74
History Note
74(73)
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2015/06/22
DNA, Circular Preferred
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