MeSH Browser

MeSH Heading: Etoposide
Tree Number(s): D02.455.426.559.847.638.960.675.250; D04.615.638.960.675.250; D09.408.348.275
Unique ID: D005047
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005047
Scope Note: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Entry Term(s): Celltop; Demethyl Epipodophyllotoxin Ethylidine Glucoside; Eposide; Eposin; Eto-GRY; Etomedac; Etopos; Etoposide Pierre Fabre; Etoposide Teva; Etoposide, (5S)-Isomer; Etoposide, (5a alpha)-Isomer; Etoposide, (5a alpha,9 alpha)-Isomer; Etoposide, alpha-D-Glucopyranosyl Isomer; Etoposido Ferrer Farma; Exitop; Lastet; NSC-141540; Onkoposid; Riboposid; Toposar; VP 16-213; VP-16; Vepesid; Vépéside-Sandoz
Pharm Action: Antineoplastic Agents, Phytogenic
Topoisomerase II Inhibitors
Related Numbers: 100007-53-2; 33419-42-0; 89301-95-1; 96554-38-0; 96554-41-5
CAS Type 1 Name: Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
NLM Classification #: QV 269
Previous Indexing: Glucosides (1975); Glycosides (1973-1974); Podophyllotoxin (1973-1974)/analogs & derivatives (1975)
Public MeSH Note: 87; was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
Online Note: use ETOPOSIDE to search VP 16-213 1976-80
History Note: 87(81); was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
Date Established: 1987/01/01
Date of Entry: 1975/07/25
Revision Date: 2018/03/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Cyclic [D02.455.426]
    - Hydrocarbons, Aromatic [D02.455.426.559]
      - Polycyclic Aromatic Hydrocarbons [D02.455.426.559.847]
        
        Naphthalenes [D02.455.426.559.847.638]
        
        Tetrahydronaphthalenes [D02.455.426.559.847.638.960]
        
        Podophyllotoxin [D02.455.426.559.847.638.960.675]
        
        Etoposide [D02.455.426.559.847.638.960.675.250]

Polycyclic Compounds [D04]
- Polycyclic Aromatic Hydrocarbons [D04.615]
  - Naphthalenes [D04.615.638]
    - Tetrahydronaphthalenes [D04.615.638.960]
      - Podophyllotoxin [D04.615.638.960.675]
        
        Etoposide [D04.615.638.960.675.250]

Carbohydrates [D09]
- Glycosides [D09.408]
  - Glucosides [D09.408.348]

Etoposide Preferred

Concept UI: M0007930
Related Numbers: 100007-53-2; 33419-42-0; 89301-95-1; 96554-38-0; 96554-41-5
Scope Note: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Terms: Etoposide Preferred Term
Term UI T015431
Date01/01/1999
LexicalTag NON
ThesaurusID; Demethyl Epipodophyllotoxin Ethylidine Glucoside
Term UI T015429
Date07/16/1975
LexicalTag NON
ThesaurusID UNK (19XX); Eposide
Term UI T015430
Date12/09/1983
LexicalTag NON
ThesaurusID UNK (19XX)