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Glutamate Decarboxylase MeSH Descriptor Data 2022


MeSH Heading
Glutamate Decarboxylase
Tree Number(s)
D08.811.520.224.125.250
Unique ID
D005968
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D005968
Scope Note
A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
Entry Term(s)
Glutamate Carboxy-Lyase
Glutamic Acid Decarboxylase
Registry Number
EC 4.1.1.15
CAS Type 1 Name
L-Glutamate-1-carboxy-lyase
Previous Indexing
Carboxy-Lyases (1973-1974)
Glutamates (1973-1974)
Public MeSH Note
84; was see under CARBOXY-LYASES 1975-83
History Note
84(75); was see under CARBOXY-LYASES 1975-83
Date Established
1984/01/01
Date of Entry
1974/11/19
Revision Date
2003/07/09
Glutamate Decarboxylase Preferred
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