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Hypoglycins MeSH Descriptor Data 2022


MeSH Heading
Hypoglycins
Tree Number(s)
D02.455.426.392.368.533.450
D23.946.412
Unique ID
D007005
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007005
Annotation
Jamaican vomiting sickness : coordinate HYPOGLYCINS /‌pois (IM) with PLANT POISONING (IM)
Scope Note
Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the AKEE plant (BLIGHIA SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a syndrome called Jamaican vomiting sickness that includes a fall in blood glucose due to the interference of FATTY ACIDS and LEUCINE metabolism which leads to VOMITING, liver damage, CONVULSIONS and DEATH.
Pharm Action
Poisons
Registry Number
0
Previous Indexing
Alanine (1973-1976)
Cyclopropanes (1970-1976)
Public MeSH Note
91; was see under CYCLOPROPANES 1977-90
History Note
91(77); was see under CYCLOPROPANES 1977-90
Date Established
1991/01/01
Date of Entry
1976/04/16
Revision Date
2005/06/30
Hypoglycins Preferred
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