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Lewis Blood Group Antigens MeSH Descriptor Data 2022


MeSH Heading
Lewis Blood Group Antigens
Tree Number(s)
D23.050.301.290.544
D23.050.705.230.544
Unique ID
D007983
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007983
Annotation
coordinate with disease /‌blood, not /‌immunol nor /‌genet
Scope Note
Carbohydrate antigens structurally related to the ABH BLOOD-GROUP SYSTEM. They may occur as a modification of saccharide chains on glycolipids or glycoproteins on cell surfaces or in plasma, or as free oligosaccharides in secretions. Lewis antigens are not synthesized in blood cells. Instead Lewis glycolipids present in plasma are absorbed onto the surface of ERYTHROCYTES; LYMPHOCYTES; and PLATELETS. The phenotypes Le(a) and Le(b) are the result of the actions of two genes the Le gene (fucosyltransferase FUT3) and the Se gene (fucosyltransferase FUT2) on the precursor carbohydrate, glycolipid or glycoprotein. Other FUCOSYLTRANSFERASES can also synthesize the Lewis antigens.
Entry Term(s)
Blood Group Lewis Related Antigens
Le Antigens
Le(a) Blood Group System
Lewis Antigen Related Tumor-Associated Antigens
Lewis Antigens
Lewis Blood Group Related Antigens
Lewis Blood Group Related Tumor-Associated Antigens
Lewis Blood-Group System
Lewis Related Antigens
Lewis System
Sialyl Lewis Antigens
Registry Number
0
Public MeSH Note
2020; see LEWIS BLOOD GROUP SYSTEM 1974-2019
History Note
2020 (1963)
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2019/07/05
Lewis Blood Group Antigens Preferred
Sialyl Lewis Antigens Related
Lewis Blood Group Related Antigens Related
Lewis Antigens Broader
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