MeSH Browser

MeSH Heading: Lewis Blood Group Antigens
Tree Number(s): D23.050.301.290.544; D23.050.705.230.544
Unique ID: D007983
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007983
Annotation: coordinate with disease /‌blood, not /‌immunol nor /‌genet
Scope Note: Carbohydrate antigens structurally related to the ABH BLOOD-GROUP SYSTEM. They may occur as a modification of saccharide chains on glycolipids or glycoproteins on cell surfaces or in plasma, or as free oligosaccharides in secretions. Lewis antigens are not synthesized in blood cells. Instead Lewis glycolipids present in plasma are absorbed onto the surface of ERYTHROCYTES; LYMPHOCYTES; and PLATELETS. The phenotypes Le(a) and Le(b) are the result of the actions of two genes the Le gene (fucosyltransferase FUT3) and the Se gene (fucosyltransferase FUT2) on the precursor carbohydrate, glycolipid or glycoprotein. Other FUCOSYLTRANSFERASES can also synthesize the Lewis antigens.
Entry Term(s): Blood Group Lewis Related Antigens; Le Antigens; Le(a) Blood Group System; Lewis Antigen Related Tumor-Associated Antigens; Lewis Antigens; Lewis Blood Group Related Antigens; Lewis Blood Group Related Tumor-Associated Antigens; Lewis Blood-Group System; Lewis Related Antigens; Lewis System; Sialyl Lewis Antigens
Registry Number: 0
Public MeSH Note: 2020; see LEWIS BLOOD GROUP SYSTEM 1974-2019
History Note: 2020 (1963)
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Blood Group Antigens [D23.050.301.290]

Biological Factors [D23]
- Antigens [D23.050]
  - Isoantigens [D23.050.705]
    - Blood Group Antigens [D23.050.705.230]

Lewis Blood Group Antigens Preferred

Concept UI: M0012441
Registry Number: 0
Scope Note: Carbohydrate antigens structurally related to the ABH BLOOD-GROUP SYSTEM. They may occur as a modification of saccharide chains on glycolipids or glycoproteins on cell surfaces or in plasma, or as free oligosaccharides in secretions. Lewis antigens are not synthesized in blood cells. Instead Lewis glycolipids present in plasma are absorbed onto the surface of ERYTHROCYTES; LYMPHOCYTES; and PLATELETS. The phenotypes Le(a) and Le(b) are the result of the actions of two genes the Le gene (fucosyltransferase FUT3) and the Se gene (fucosyltransferase FUT2) on the precursor carbohydrate, glycolipid or glycoprotein. Other FUCOSYLTRANSFERASES can also synthesize the Lewis antigens.
Terms: Lewis Blood Group Antigens Preferred Term
Term UI T000952655
Date03/07/2019
LexicalTag EPO
ThesaurusID NLM (2020); Lewis Blood-Group System
Term UI T023797
Date01/01/1999
LexicalTag EPO
ThesaurusID NLM (1963); Lewis System
Term UI T023798
Date07/19/1975
LexicalTag EPO
ThesaurusID UNK (19XX); Le(a) Blood Group System
Term UI T023796
Date09/20/1984
LexicalTag ABX
ThesaurusID UNK (19XX)

Sialyl Lewis Antigens Related

Lewis Blood Group Related Antigens Related

Concept UI: M000647636
Registry Number: 0
Scope Note: Carbohydrate antigens structurally related to the Lewis blood group system antigens. They include substrates for the Le gene product, Le(c) and Le(d); ISOANTIGENS of the Lewis antigens; sialated versions of the Lewis antigens and their isoantigens; and other derivatives of the Le antigens and their isoantigens. They are indicated as so with the word Lewis or the letters Le in the name or abbreviation of the antigen.
Terms: Lewis Blood Group Related Antigens Preferred Term
Term UI T000952651
Date03/07/2019
LexicalTag EPO
ThesaurusID NLM (2020); Lewis Blood Group Related Tumor-Associated Antigens
Term UI T000952654
Date03/07/2019
LexicalTag EPO
ThesaurusID NLM (2020); Lewis Antigen Related Tumor-Associated Antigens
Term UI T000952653
Date03/07/2019
LexicalTag EPO
ThesaurusID NLM (2020); Lewis Related Antigens
Term UI T000952646
Date03/07/2019
LexicalTag EPO
ThesaurusID NLM (2020); Blood Group Lewis Related Antigens
Term UI T000952652
Date03/07/2019
LexicalTag NON
ThesaurusID NLM (2020)

Lewis Antigens Broader

Lewis Blood Group Antigens MeSH Descriptor Data 2024