MeSH Browser

MeSH Heading: Mitotane
Tree Number(s): D02.455.526.439.681
Unique ID: D008939
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008939
Scope Note: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Entry Term(s): Chloditan; Chlodithane; Khloditan; Lysodren; Mytotan; o,p-DDD; ortho,para-DDD
Pharm Action: Antineoplastic Agents, Hormonal
Registry Number: 78E4J5IB5J
Related Numbers: 53-19-0
CAS Type 1 Name: Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-
Previous Indexing: DDD/PD (1966-1972)
Public MeSH Note: 73
History Note: 73
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0013951
Registry Number: 78E4J5IB5J
Related Numbers: 53-19-0
Scope Note: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Terms: Mitotane Preferred Term
Term UI T026718
Date01/01/1999
LexicalTag NON
ThesaurusID; o,p-DDD
Term UI T026721
Date05/17/1976
LexicalTag NON
ThesaurusID UNK (19XX); Mytotan
Term UI T026723
Date10/07/1986
LexicalTag NON
ThesaurusID UNK (19XX); ortho,para-DDD
Term UI T026719
Date05/17/1976
LexicalTag NON
ThesaurusID UNK (19XX)

Mitotane MeSH Descriptor Data 2024