Strains of MURINE LEUKEMIA VIRUS that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (LEUKEMIA, ERYTHROBLASTIC, ACUTE), manifested by splenic foci, SPLENOMEGALY, and POLYCYTHEMIA. Spleen focus-forming viruses are generated by recombination with endogenous retroviral sequences.
Entry Term(s)
Friend spleen focus-forming virus
Rauscher Spleen Focus-Forming Virus
SFFV
Related Numbers
txid11820
txid11821
Previous Indexing
Friend Virus (1966-1985)
Leukemia, Experimental (1966-1985)
Mouse Leukemia Viruses (1966-1985)
Public MeSH Note
91; was see under MOUSE LEUKEMIA VIRUSES 1986-90
History Note
91(86); was see under MOUSE LEUKEMIA VIRUSES 1986-90
Strains of MURINE LEUKEMIA VIRUS that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (LEUKEMIA, ERYTHROBLASTIC, ACUTE), manifested by splenic foci, SPLENOMEGALY, and POLYCYTHEMIA. Spleen focus-forming viruses are generated by recombination with endogenous retroviral sequences.