MeSH Browser

MeSH Heading: Sulindac
Tree Number(s): D02.455.426.559.847.486.875; D04.615.486.875
Unique ID: D013467
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013467
Scope Note: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Entry Term(s): Aclin; Apo-Sulin; Arthrobid; Arthrocine; Chibret; Clinoril; Copal; Kenalin; Klinoril; MK-231; Novo-Sundac; Nu-Sulindac; Sulindal
Pharm Action: Anti-Inflammatory Agents, Non-Steroidal
Antineoplastic Agents
Cyclooxygenase Inhibitors
Registry Number: 184SNS8VUH
Related Numbers: 38194-50-2
CAS Type 1 Name: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-
Previous Indexing: Benzene (1966-1967); Benzene Derivatives (1968-1974); Benzylidene Compounds (1975-1978); Indenes (1966-1978)
Public MeSH Note: 90; was see under INDENES 1979-89
History Note: 90(79); was see under INDENES 1979-89
Date Established: 1990/01/01
Date of Entry: 1978/02/08
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Sulindac MeSH Descriptor Data 2024