MeSH Browser

MeSH Heading: Tacrine
Tree Number(s): D03.633.300.046.250.900
Unique ID: D013619
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013619
Scope Note: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
Entry Term(s): 1,2,3,4-Tetrahydro-9-acridinamine; 1,2,3,4-Tetrahydroaminoacridine; 9-Amino-1,2,3,4-Tetrahydroacridine; Cognex; Romotal; THA; Tacrine Hydrochloride; Tenakrin; Tetrahydroaminoacridine
Pharm Action: Cholinesterase Inhibitors
Parasympathomimetics
Nootropic Agents
Registry Numbers: 4VX7YNB537; 0; 4966RNG0BU
Related Numbers: 1684-40-8; 321-64-2; 4966RNG0BU
CAS Type 1 Name: 9-Acridinamine, 1,2,3,4-tetrahydro-
Previous Indexing: Acridines (1969-1974); Amines (1972-1974)
Public MeSH Note: 91; was see under AMINOACRIDINES 1984-90; was see under ACRIDINES 1975-83
History Note: 91(75); was see under AMINOACRIDINES 1984-90; was see under ACRIDINES 1975-83
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0021008
Registry Numbers: 4VX7YNB537
Related Numbers: 1684-40-8; 321-64-2; 4966RNG0BU
Scope Note: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
Terms: Tacrine Preferred Term
Term UI T039998
Date01/01/1999
LexicalTag NON
ThesaurusID; 1,2,3,4-Tetrahydroaminoacridine
Term UI T039996
Date11/14/1986
LexicalTag NON
ThesaurusID UNK (19XX); 9-Amino-1,2,3,4-Tetrahydroacridine
Term UI T039997
Date07/19/1988
LexicalTag NON
ThesaurusID UNK (19XX); Tetrahydroaminoacridine
Term UI T040000
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX); 1,2,3,4-Tetrahydro-9-acridinamine
Term UI T040001
Date03/24/1994
LexicalTag NON
ThesaurusID NLM (1995)

Tacrine MeSH Descriptor Data 2024