MeSH Browser

MeSH Heading: Cholinesterase Inhibitors
Tree Number(s): D27.505.519.389.275; D27.505.519.625.120.300; D27.505.696.577.120.300
Unique ID: D002800
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002800
Scope Note: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
Entry Version: CHOLINESTERASE INHIB
Entry Term(s): Acetylcholinesterase Inhibitor; Acetylcholinesterase Inhibitors; Anti-Cholinesterase; Anti-Cholinesterases; Anticholinesterase; Anticholinesterase Agent; Anticholinesterase Agents; Anticholinesterase Drug; Anticholinesterase Drugs; Anticholinesterases; Cholinesterase Inhibitor; Cholinesterase Inhibitors, Irreversible; Cholinesterase Inhibitors, Reversible
NLM Classification #: QV 124
See Also: Insecticides
Public MeSH Note: 65; CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE were see under CHOLINESTERASE INHIBITORS 1975-83; CHOLINESTERASE INHIBITORS, ORGANIC was see PHOSPHORUS POISONS, ORGANIC 1963-64 (PHOSPHORUS POISONS, ORGANIC deleted 1965)
Online Note: use CHOLINESTERASE INHIBITORS to search CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE 1971-83 (as Prov 1971-74)
History Note: 65; CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE were see under CHOLINESTERASE INHIBITORS 1975-83, were Prov 1971-74; CHOLINESTERASE INHIBITORS, ORGANIC was see PHOSPHORUS POISONS, ORGANIC 1963-64 (PHOSPHORUS POISONS, ORGANIC deleted 1965)
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Molecular Mechanisms of Pharmacological Action [D27.505.519]
    - Enzyme Inhibitors [D27.505.519.389]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Molecular Mechanisms of Pharmacological Action [D27.505.519]
    - Neurotransmitter Agents [D27.505.519.625]
      - Cholinergic Agents [D27.505.519.625.120]
        
        Acetylcholine Release Inhibitors [D27.505.519.625.120.069]
        
        Cholinergic Agonists [D27.505.519.625.120.140]
        
        Cholinergic Antagonists [D27.505.519.625.120.200]
        
        Cholinesterase Inhibitors [D27.505.519.625.120.300]
        
        Cholinesterase Reactivators [D27.505.519.625.120.400]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Physiological Effects of Drugs [D27.505.696]
    - Neurotransmitter Agents [D27.505.696.577]
      - Cholinergic Agents [D27.505.696.577.120]
        
        Acetylcholine Release Inhibitors [D27.505.696.577.120.069]
        
        Cholinergic Agonists [D27.505.696.577.120.140]
        
        Cholinergic Antagonists [D27.505.696.577.120.200]
        
        Cholinesterase Inhibitors [D27.505.696.577.120.300]
        
        Cholinesterase Reactivators [D27.505.696.577.120.400]

Cholinesterase Inhibitors Preferred

Concept UI: M0004295
Scope Note: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
Terms: Cholinesterase Inhibitors Preferred Term
Term UI T008158
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1965); Anti-Cholinesterase
Term UI T000998051
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Anticholinesterase Agent
Term UI T000998053
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Anticholinesterase Drug
Term UI T000998054
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Cholinesterase Inhibitor
Term UI T000996486
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); Anticholinesterase
Term UI T000996435
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); Anticholinesterase Agents
Term UI T008157
Date03/29/1974
LexicalTag NON
ThesaurusID UNK (19XX); Anti-Cholinesterases
Term UI T008159
Date02/04/1994
LexicalTag NON
ThesaurusID NLM (1995); Anticholinesterases
Term UI T008160
Date02/04/1994
LexicalTag NON
ThesaurusID NLM (1995); Anticholinesterase Drugs
Term UI T008161
Date05/18/1995
LexicalTag NON
ThesaurusID NLM (1996)

Acetylcholinesterase Inhibitors Narrower

Cholinesterase Inhibitors, Irreversible Narrower

Cholinesterase Inhibitors, Reversible Narrower

Cholinesterase Inhibitors MeSH Descriptor Data 2024