MeSH Browser

MeSH Heading: Thiotepa
Tree Number(s): D02.705.672.875; D03.383.097.217.935.960
Unique ID: D013852
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013852
Scope Note: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Entry Term(s): AI3-24916; Girostan; NSC-6396; Tespa; Tespamin; Thio-Tepa; Thiophosphamide; Triethylenethiophosphoramide; Tris(1-aziridinyl)phosphine Sulfide
Pharm Action: Antineoplastic Agents, Alkylating
Myeloablative Agonists
Related Numbers: 52-24-4
CAS Type 1 Name: Aziridine, 1,1',1''-phosphinothioylidynetris-
NLM Classification #: QV 269
Public MeSH Note: 92; was THIO-TEPA 1963-91; THIOTEPA was see THIO-TEPA 1977-91
Online Note: use THIOTEPA to search THIO-TEPA 1966-91
History Note: 92; was THIO-TEPA 1963-91; THIOTEPA was see THIO-TEPA 1977-91
Date Established: 1992/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0021343
Related Numbers: 52-24-4
Scope Note: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Terms: Thiotepa Preferred Term
Term UI T040671
Date01/01/1999
LexicalTag NON
ThesaurusID; Thiophosphamide
Term UI T040672
Date05/15/1976
LexicalTag NON
ThesaurusID UNK (19XX); Triethylenethiophosphoramide
Term UI T040673
Date04/04/1991
LexicalTag NON
ThesaurusID NLM (1992); Tris(1-aziridinyl)phosphine Sulfide
Term UI T040674
Date04/04/1991
LexicalTag NON
ThesaurusID NLM (1992); Thio-Tepa
Term UI T040675
Date03/24/1976
LexicalTag NON
ThesaurusID UNK (19XX)

Thiotepa MeSH Descriptor Data 2024