MeSH Browser

MeSH Heading: Neurotransmitter Uptake Inhibitors
Tree Number(s): D27.505.519.562.437; D27.505.519.625.600; D27.505.696.577.600
Unique ID: D014179
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014179
Annotation: general or unspecified; prefer specific groups or specific drugs; coordinate with specific neurotransmitters /‌physiol
Scope Note: Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
Entry Version: NEUROTRANSM UPTAKE INHIB
Entry Term(s): Inhibitors, Neurotransmitter Uptake; Reuptake Inhibitors, Neurotransmitter; Transmitter Uptake Inhibitors, Neuronal; Uptake Inhibitors, Neurotransmitter
Registry Number: 0
NLM Classification #: QV 126
Previous Indexing: Cytoplasmic Granules (1966-1977); Kinetics (1966-1984); Nerve Endings (1966-1973); Synapses (1966-1971); Synaptic Vesicles (1972-1973); Synaptosomes (1974-1984)
Public MeSH Note: 93; was TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92; NEUROTRANSMITTER UPTAKE INHIBITORS, INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER were see TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92
Online Note: use NEUROTRANSMITTER UPTAKE INHIBITORS to search TRANSMITTER UPTAKE INHIBITORS, NEURONAL; INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER 1985-92
History Note: 93; WAS TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92; NEUROTRANSMITTER UPTAKE INHIBITORS, INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER were see TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92
Date Established: 1985/01/01
Date of Entry: 1984/05/01
Revision Date: 2019/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Molecular Mechanisms of Pharmacological Action [D27.505.519]
    - Membrane Transport Modulators [D27.505.519.562]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Molecular Mechanisms of Pharmacological Action [D27.505.519]
    - Neurotransmitter Agents [D27.505.519.625]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Physiological Effects of Drugs [D27.505.696]
    - Neurotransmitter Agents [D27.505.696.577]

Neurotransmitter Uptake Inhibitors Preferred

Concept UI: M0021830
Registry Number: 0
Scope Note: Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
Terms: Neurotransmitter Uptake Inhibitors Preferred Term
Term UI T041540
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1985); Uptake Inhibitors, Neurotransmitter
Term UI T041539
Date04/14/1992
LexicalTag NON
ThesaurusID NLM (1993); Reuptake Inhibitors, Neurotransmitter
Term UI T041542
Date05/06/1992
LexicalTag NON
ThesaurusID NLM (1993); Transmitter Uptake Inhibitors, Neuronal
Term UI T041541
Date04/14/1992
LexicalTag NON
ThesaurusID NLM (1993); Inhibitors, Neurotransmitter Uptake
Term UI T041538
Date05/01/1984
LexicalTag NON
ThesaurusID UNK (19XX)

Neurotransmitter Uptake Inhibitors MeSH Descriptor Data 2024