MeSH Browser

MeSH Heading: Valproic Acid
Tree Number(s): D02.241.081.944.509.900; D10.251.400.895.593.900
Unique ID: D014635
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014635
Scope Note: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
Entry Term(s): 2-Propylpentanoic Acid; Calcium Valproate; Convulsofin; Depakene; Depakine; Depakote; Dipropyl Acetate; Divalproex; Divalproex Sodium; Ergenyl; Magnesium Valproate; Propylisopropylacetic Acid; Semisodium Valproate; Sodium Valproate; Valproate; Valproate Calcium; Valproate Sodium; Valproic Acid, Sodium Salt (2:1); Vupral
Pharm Action: Anticonvulsants
Enzyme Inhibitors
GABA Agents
Antimanic Agents
Related Numbers: 56CCK4F86G; 5VOM6GYJ0D; 644VL95AO6; 76584-70-8; 99-66-1; Q400352CM2
CAS Type 1 Name: Pentanoic acid, 2-propyl-
NLM Classification #: QV 85
Previous Indexing: Valerates (1966-1974)
Public MeSH Note: 1991; was VALPROATE 1979-1990; was DIPROPYL ACETATE see under VALERATES 1975-1978
Online Note: use VALPROIC ACID to search VALPROATE 1979-90 & DIPROPYL ACETATE 1975-90
History Note: 1991; was VALPROATE 1979-1990; was DIPROPYL ACETATE see under VALERATES 1975-1978
Date Established: 1979/01/01
Date of Entry: 1974/11/11
Revision Date: 2018/06/19

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Carboxylic Acids [D02.241]
  - Acids, Acyclic [D02.241.081]
    - Valerates [D02.241.081.944]
      - Pentanoic Acids [D02.241.081.944.509]
        
        Gemfibrozil [D02.241.081.944.509.350]
        
        Valproic Acid [D02.241.081.944.509.900]

Lipids [D10]
- Fatty Acids [D10.251]
  - Fatty Acids, Volatile [D10.251.400]
    - Valerates [D10.251.400.895]
      - Pentanoic Acids [D10.251.400.895.593]
        
        Gemfibrozil [D10.251.400.895.593.350]
        
        Valproic Acid [D10.251.400.895.593.900]

Valproic Acid Preferred

Concept UI: M0022501
Related Numbers: 56CCK4F86G; 5VOM6GYJ0D; 644VL95AO6; 76584-70-8; 99-66-1; Q400352CM2
Scope Note: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
Terms: Valproic Acid Preferred Term
Term UI T042800
Date01/01/1999
LexicalTag NON
ThesaurusID; Divalproex
Term UI T042799
Date05/24/1988
LexicalTag NON
ThesaurusID UNK (19XX); 2-Propylpentanoic Acid
Term UI T042801
Date05/18/1995
LexicalTag NON
ThesaurusID NLM (1996)

Valproate Sodium Narrower

Valproate Narrower

Dipropyl Acetate Related

Magnesium Valproate Narrower

Divalproex Sodium Narrower

Depakote Narrower

Vupral Narrower

Ergenyl Narrower

Depakene Narrower

Convulsofin Narrower

Depakine Narrower

Valproic Acid, Sodium Salt (2:1) Narrower

Calcium Valproate Narrower

Propylisopropylacetic Acid Related

Valproic Acid MeSH Descriptor Data 2024