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Meglutol MeSH Descriptor Data 2024


MeSH Heading
Meglutol
Tree Number(s)
D02.241.081.337.351.550
Unique ID
D015093
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015093
Scope Note
An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
Entry Term(s)
3-Hydroxy-3-methylglutaric Acid
3-Hydroxy-3-methylpentanedioic Acid
beta-Hydroxy-beta-Methylglutarate
Pharm Action
Anticholesteremic Agents
Hypolipidemic Agents
Enzyme Inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Related Numbers
503-49-1
CAS Type 1 Name
Pentanedioic acid, 3-hydroxy-3-methyl-
Previous Indexing
Anticholesteremic Agents (1966-1979)
Antilipemic Agents (1966-1972)
Glutarates (1966-1979)
Hydroxy Acids (1975-1979)
Public MeSH Note
96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)
History Note
96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)
Date Established
1991/01/01
Date of Entry
1979/05/23
Revision Date
2013/07/08
Meglutol Preferred
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