MeSH Browser

MeSH Heading: DNA Probes
Tree Number(s): D13.444.600.223; D27.505.259.750.600.223; D27.720.470.530.600.223
Unique ID: D015342
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015342
Annotation: general or unspecified; prefer specifics
Scope Note: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Entry Term(s): Chromosomal Probes; Conserved Gene Probes; DNA Hybridization Probe; DNA Hybridization Probes; DNA Probe; Gene Probes, DNA; Whole Chromosomal Probes; Whole Genomic DNA Probes
NLM Classification #: QU 58.5
Previous Indexing: DNA or specific DNA (1972-1988); Nucleic Acid Hybridization (1972-1988)
See Also: Chromosome Walking
Public MeSH Note: 89
History Note: 89
Date Established: 1989/01/01
Date of Entry: 1988/06/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0023617
Scope Note: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Terms: DNA Probes Preferred Term
Term UI T045149
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1989); DNA Probe
Term UI T001006061
Date01/23/2020
LexicalTag NON
ThesaurusID NLM (2021); DNA Hybridization Probe
Term UI T001006062
Date01/23/2020
LexicalTag NON
ThesaurusID NLM (2021); DNA Hybridization Probes
Term UI T045148
Date06/01/1988
LexicalTag NON
ThesaurusID UNK (19XX)

DNA Probes MeSH Descriptor Data 2024