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DNA Probes MeSH Descriptor Data 2024


MeSH Heading
DNA Probes
Tree Number(s)
D13.444.600.223
D27.505.259.750.600.223
D27.720.470.530.600.223
Unique ID
D015342
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015342
Annotation
general or unspecified; prefer specifics
Scope Note
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Entry Term(s)
Chromosomal Probes
Conserved Gene Probes
DNA Hybridization Probe
DNA Hybridization Probes
DNA Probe
Gene Probes, DNA
Whole Chromosomal Probes
Whole Genomic DNA Probes
Registry Number
0
NLM Classification #
QU 58.5
Previous Indexing
DNA or specific DNA (1972-1988)
Nucleic Acid Hybridization (1972-1988)
See Also
Chromosome Walking
Public MeSH Note
89
History Note
89
Date Established
1989/01/01
Date of Entry
1988/06/01
Revision Date
2020/05/27
DNA Probes Preferred
Whole Genomic DNA Probes Narrower
Gene Probes, DNA Narrower
Whole Chromosomal Probes Narrower
Chromosomal Probes Narrower
Conserved Gene Probes Narrower
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