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Nimustine MeSH Descriptor Data 2022


MeSH Heading
Nimustine
Tree Number(s)
D02.065.950.594.550
D02.654.692.550
Unique ID
D015376
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015376
Scope Note
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
Entry Term(s)
ACNU
NSC 245382
Pharm Action
Antineoplastic Agents
Registry Number
0S726V972K
Related Numbers
42471-28-3
CAS Type 1 Name
Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-
Previous Indexing
Antineoplastic Agents (1975-1988)
Nitrosourea Compounds (1975-1988)
Public MeSH Note
89
History Note
89
Date Established
1989/01/01
Date of Entry
1988/06/03
Revision Date
2020/05/27
Nimustine Preferred
NSC 245382 Narrower
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