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Pentostatin MeSH Descriptor Data 2022


MeSH Heading
Pentostatin
Tree Number(s)
D03.383.742.680.350.200.700
D13.570.230.677
D13.570.685.350.200.700
Unique ID
D015649
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015649
Scope Note
A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Entry Term(s)
2'-Deoxycoformycin
CI-825
Co-Vidarabine
Deoxycoformycin
Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
NSC-218321
Nipent
Pharm Action
Antineoplastic Agents
Adenosine Deaminase Inhibitors
Registry Number
395575MZO7
Related Numbers
53910-25-1
CAS Type 1 Name
Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-
Previous Indexing
Azepines (1966-1978)
Coformycin/analogs & derivatives (1979-1989)
Deoxyribonucleosides (1971-1978)
Public MeSH Note
1997; CO-VIDARABINE (now PENTOSTATIN) was indexed under VIDARABINE/*analogs & derivatives 1976-97
History Note
1997 (1990); for CO-VIDARABINE use PENTOSTATIN 1982-1997
Date Established
1990/01/01
Date of Entry
1989/05/25
Revision Date
2019/07/01
Pentostatin Preferred
Deoxycoformycin Related
NSC-218321 Narrower
Co-Vidarabine Related
CI-825 Narrower
Nipent Narrower
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