MeSH Browser

MeSH Heading: 1-Methyl-4-phenylpyridinium
Tree Number(s): D03.383.725.762.550
Unique ID: D015655
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015655
Scope Note: An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Entry Term(s): 1-Methyl-4-phenylpyridine; 1-Methyl-4-phenylpyridinium Chloride; 1-Methyl-4-phenylpyridinium Ion; Cyperquat; N-Methyl-4-phenylpyridine; N-Methyl-4-phenylpyridinium
Pharm Action: Herbicides
Related Numbers: 39794-99-5; 48134-75-4; MRP3DNB9K9
CAS Type 1 Name: Pyridinium, 1-methyl-4-phenyl-
Previous Indexing: Pyridinium Compounds (1968-1989)
See Also: MPTP Poisoning
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/05/16
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0023993
Related Numbers: 39794-99-5; 48134-75-4; MRP3DNB9K9
Scope Note: An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Terms: 1-Methyl-4-phenylpyridinium Preferred Term
Term UI T046314
Date01/01/1999
LexicalTag NON
ThesaurusID; 1-Methyl-4-phenylpyridinium Ion
Term UI T046315
Date02/02/1989
LexicalTag NON
ThesaurusID; Cyperquat
Term UI T046316
Date02/02/1989
LexicalTag NON
ThesaurusID; N-Methyl-4-phenylpyridinium
Term UI T046318
Date02/02/1989
LexicalTag NON
ThesaurusID; N-Methyl-4-phenylpyridine
Term UI T046319
Date02/02/1989
LexicalTag NON
ThesaurusID; 1-Methyl-4-phenylpyridine
Term UI T046320
Date02/02/1989
LexicalTag NON
ThesaurusID NLM (1990)

1-Methyl-4-phenylpyridinium MeSH Descriptor Data 2024