NLM Logo

1-Methyl-4-phenylpyridinium MeSH Descriptor Data 2022


MeSH Heading
1-Methyl-4-phenylpyridinium
Tree Number(s)
D03.383.725.762.550
Unique ID
D015655
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015655
Scope Note
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Entry Term(s)
1-Methyl-4-phenylpyridine
1-Methyl-4-phenylpyridinium Chloride
1-Methyl-4-phenylpyridinium Ion
Cyperquat
N-Methyl-4-phenylpyridine
N-Methyl-4-phenylpyridinium
Pharm Action
Herbicides
Registry Number
R865A5OY8J
Related Numbers
39794-99-5
48134-75-4
MRP3DNB9K9
CAS Type 1 Name
Pyridinium, 1-methyl-4-phenyl-
Previous Indexing
Pyridinium Compounds (1968-1989)
See Also
MPTP Poisoning
Public MeSH Note
90
History Note
90
Date Established
1990/01/01
Date of Entry
1989/05/16
Revision Date
2016/05/27
1-Methyl-4-phenylpyridinium Preferred
1-Methyl-4-phenylpyridinium Chloride Narrower
page delivered in 0.139s