- Concept UI
- M0023993
- Registry Numbers
- R865A5OY8J
- Related Numbers
- 39794-99-5
- 48134-75-4
- MRP3DNB9K9
- Scope Note
- An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
- Terms
-
1-Methyl-4-phenylpyridinium
Preferred Term
Term UI
T046314
Date01/01/1999
LexicalTag
NON
ThesaurusID
-
1-Methyl-4-phenylpyridinium Ion
Term UI
T046315
Date02/02/1989
LexicalTag
NON
ThesaurusID
-
Cyperquat
Term UI
T046316
Date02/02/1989
LexicalTag
NON
ThesaurusID
-
N-Methyl-4-phenylpyridinium
Term UI
T046318
Date02/02/1989
LexicalTag
NON
ThesaurusID
-
N-Methyl-4-phenylpyridine
Term UI
T046319
Date02/02/1989
LexicalTag
NON
ThesaurusID
-
1-Methyl-4-phenylpyridine
Term UI
T046320
Date02/02/1989
LexicalTag
NON
ThesaurusID
NLM (1990)