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Osteocalcin MeSH Descriptor Data 2022


MeSH Heading
Osteocalcin
Tree Number(s)
D12.776.157.125.700
Unique ID
D015675
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015675
Scope Note
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Entry Term(s)
4-Carboxyglutamic Protein, Bone
Bone Gla Protein
Bone gamma-Carboxyglutamic Acid Protein
Calcium-Binding Protein, Vitamin K-Dependent
Gla Protein, Bone
Vitamin K-Dependent Bone Protein
Registry Number
104982-03-8
CAS Type 1 Name
Osteocalcin (human reduced), 3-de-L-tyrosine-4-de-L-glutamine-5-de-L-tryptophan-6-de-L-leucine-9-L-serine-12-L-serine-19-L-threonine-22-L-glutamine-28-L-alanine-33-L-serine-35-L-glutamine-36-L-tyrosine-38-L-leucine-39-L-lysine-40-L-threonine-43-L-lysine-45-L-isoleucine-48-L-isoleucine-49-L-threonine-49a-L-isoleucine-
Previous Indexing
1-Carboxyglutamic Acid (1978-1981)
Binding Proteins (1978-1980)
Calcium (1978-1980)
Calcium-Binding Proteins (1980-1989)
Proteins (1980-1981)
Public MeSH Note
90; GLA-PROTEIN was see OSTEOCALCIN 1990-96
Online Note
use OSTEOCALCIN to search GLA-PROTEIN 1990-96
History Note
90; GLA-PROTEIN was see OSTEOCACLIN 1990-96
Date Established
1990/01/01
Date of Entry
1989/09/06
Revision Date
2004/07/07
Osteocalcin Preferred
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