MeSH Browser

MeSH Heading: Granulocyte-Macrophage Colony-Stimulating Factor
Tree Number(s): D09.400.430.775.300; D12.644.276.374.410.240.375; D12.776.395.240.300; D12.776.467.374.410.240.375; D23.529.374.410.240.375
Unique ID: D016178
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016178
Scope Note: An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Entry Version: GMCSF
Entry Term(s): CSF-2; CSF-GM; Colony-Stimulating Factor, Granulocyte-Macrophage; GM-CSF; Histamine-Producing Cell-Stimulating Factor; TC-GM-CSF; Tumor-Cell Human GM Colony-Stimulating Factor
CAS Type 1 Name: Colony-stimulating factor 2
Previous Indexing: Colony-Stimulating Factors (1976-1990); Growth Substances (1966-1990); Interleukin-3 (1981-1987)
See Also: Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
Public MeSH Note: 91; HISTAMINE-PRODUCING CELL-STIMULATING FACTOR was HISTAMINE-PRODUCING CELL STIMULATING FACTOR see INTERLEUKIN-3 1987-91
Online Note: use INTERLEUKIN-3 to search HISTAMINE-PRODUCING CELL-STIMULATING FACTOR 1987-91
History Note: 91; HISTAMINE-PRODUCING CELL-STIMULATING FACTOR was HISTAMINE-PRODUCING CELL STIMULATING FACTOR see INTERLEUKIN-3 1987-91
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Colony-Stimulating Factors [D09.400.430.775]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Hematopoietic Cell Growth Factors [D12.644.276.374.410]
        
        Colony-Stimulating Factors [D12.644.276.374.410.240]
        
        Erythropoietin [D12.644.276.374.410.240.150]
        
        Granulocyte Colony-Stimulating Factor [D12.644.276.374.410.240.350]
        
        Granulocyte-Macrophage Colony-Stimulating Factor [D12.644.276.374.410.240.375]
        
        Interleukin-3 [D12.644.276.374.410.240.400]
        
        Macrophage Colony-Stimulating Factor [D12.644.276.374.410.240.500]
        
        Thrombopoietin [D12.644.276.374.410.240.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Colony-Stimulating Factors [D12.776.395.240]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Hematopoietic Cell Growth Factors [D12.776.467.374.410]
        
        Colony-Stimulating Factors [D12.776.467.374.410.240]
        
        Erythropoietin [D12.776.467.374.410.240.150]
        
        Granulocyte Colony-Stimulating Factor [D12.776.467.374.410.240.350]
        
        Granulocyte-Macrophage Colony-Stimulating Factor [D12.776.467.374.410.240.375]
        
        Interleukin-3 [D12.776.467.374.410.240.400]
        
        Macrophage Colony-Stimulating Factor [D12.776.467.374.410.240.500]
        
        Thrombopoietin [D12.776.467.374.410.240.750]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Hematopoietic Cell Growth Factors [D23.529.374.410]
      - Colony-Stimulating Factors [D23.529.374.410.240]
        
        Erythropoietin [D23.529.374.410.240.150]
        
        Granulocyte Colony-Stimulating Factor [D23.529.374.410.240.350]
        
        Granulocyte-Macrophage Colony-Stimulating Factor [D23.529.374.410.240.375]
        
        Interleukin-3 [D23.529.374.410.240.400]
        
        Macrophage Colony-Stimulating Factor [D23.529.374.410.240.500]
        
        Thrombopoietin [D23.529.374.410.240.750]

Granulocyte-Macrophage Colony-Stimulating Factor Preferred

Concept UI: M0024695
Scope Note: An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Terms: Granulocyte-Macrophage Colony-Stimulating Factor Preferred Term
Term UI T048057
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); CSF-2
Term UI T048053
Date02/15/1990
LexicalTag ABB
ThesaurusID NLM (1991); CSF-GM
Term UI T048054
Date02/15/1990
LexicalTag ABB
ThesaurusID NLM (1991); GM-CSF
Term UI T048055
Date02/15/1990
LexicalTag ABB
ThesaurusID NLM (1991); Colony-Stimulating Factor, Granulocyte-Macrophage
Term UI T048056
Date02/15/1990
LexicalTag NON
ThesaurusID NLM (1991); TC-GM-CSF
Term UI T048058
Date02/15/1990
LexicalTag ABB
ThesaurusID NLM (1991); Histamine-Producing Cell-Stimulating Factor
Term UI T048052
Date05/03/1991
LexicalTag NON
ThesaurusID NLM (1992); Tumor-Cell Human GM Colony-Stimulating Factor
Term UI T048059
Date02/15/1990
LexicalTag NON
ThesaurusID NLM (1991)

Granulocyte-Macrophage Colony-Stimulating Factor MeSH Descriptor Data 2024