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Dizocilpine Maleate MeSH Descriptor Data 2023


MeSH Heading
Dizocilpine Maleate
Tree Number(s)
D02.455.426.559.847.181.384.380
D04.615.181.384.380
Unique ID
D016291
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016291
Scope Note
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
Entry Term(s)
Dizocilpine
MK-801
Pharm Action
Excitatory Amino Acid Antagonists
Neuroprotective Agents
Registry Number
6LR8C1B66Q
Related Numbers
77086-21-6
77086-22-7
7PY8KH681I
CAS Type 1 Name
5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1)
Previous Indexing
Anticonvulsants (1966-1990)
Dibenzocycloheptenes (1968-1990)
Public MeSH Note
91
History Note
91
Date Established
1991/01/01
Date of Entry
1990/05/25
Revision Date
2013/07/08
Dizocilpine Maleate Preferred
Dizocilpine Narrower
MK-801 Narrower
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