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Superantigens MeSH Descriptor Data 2023


MeSH Heading
Superantigens
Tree Number(s)
D23.050.820
Unique ID
D018089
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018089
Annotation
coordinate IM with specific microbe /‌immunol (IM); for interaction of superantigens with endotoxins, coordinate with ENDOTOXINS or specifics
Scope Note
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
Entry Term(s)
Superantigen
Registry Number
0
NLM Classification #
QW 573
Previous Indexing
specific antigens (1989-1993)
See Also
Apoptosis
Clonal Anergy
Receptors, Antigen, T-Cell, alpha-beta
Public MeSH Note
94
History Note
94
Date Established
1994/01/01
Date of Entry
1993/07/01
Revision Date
2020/05/27
Superantigens Preferred
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