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GABA Modulators MeSH Descriptor Data 2022


MeSH Heading
GABA Modulators
Tree Number(s)
D27.505.519.625.240.500
D27.505.696.577.240.500
Unique ID
D018757
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018757
Annotation
general or unspecified; prefer specifics
Scope Note
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Entry Term(s)
GABAergic Modulators
gamma-Aminobutyric Acid Modulators
Registry Number
0
See Also
Anesthetics, General
Anti-Anxiety Agents
Hypnotics and Sedatives
Public MeSH Note
95
History Note
95
Date Established
1995/01/01
Date of Entry
1994/06/03
Revision Date
2005/06/30
GABA Modulators Preferred
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