MeSH Browser

MeSH Heading: GABA Modulators
Tree Number(s): D27.505.519.625.240.500; D27.505.696.577.240.500
Unique ID: D018757
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018757
Annotation: general or unspecified; prefer specifics
Scope Note: Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Entry Term(s): GABAergic Modulators; gamma-Aminobutyric Acid Modulators
Registry Numbers: 0
See Also: Anesthetics, General; Anti-Anxiety Agents; Hypnotics and Sedatives
Public MeSH Note: 95
History Note: 95
Date Established: 1995/01/01
Date of Entry: 1994/06/03
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0028093
Registry Numbers: 0
Scope Note: Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Terms: GABA Modulators Preferred Term
Term UI T055859
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1995); gamma-Aminobutyric Acid Modulators
Term UI T055858
Date05/13/1994
LexicalTag NON
ThesaurusID NLM (1995); GABAergic Modulators
Term UI T055860
Date02/14/1994
LexicalTag NON
ThesaurusID NLM (1995)

GABA Modulators MeSH Descriptor Data 2025