MeSH Browser

MeSH Heading: Receptors, GABA-A
Tree Number(s): D12.776.157.530.400.175.562; D12.776.157.530.400.400.100.100; D12.776.543.550.450.175.562; D12.776.543.550.450.500.100.100; D12.776.543.585.400.175.562; D12.776.543.585.400.500.100.100; D12.776.543.750.130.500; D12.776.543.750.720.200.300.300
Unique ID: D011963
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011963
Scope Note: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.
Entry Version: RECEPT GABA A
Entry Term(s): Benzodiazepine Receptor; Benzodiazepine Receptors; Benzodiazepine-GABA Receptor; Benzodiazepine-Gaba Receptors; Diazepam Receptor; Diazepam Receptors; GABA(A) Receptor; GABA-A Receptor; GABA-A Receptor alpha Subunit; GABA-A Receptor beta Subunit; GABA-A Receptor delta Subunit; GABA-A Receptor epsilon Subunit; GABA-A Receptor gamma Subunit; GABA-A Receptor rho Subunit; GABA-A Receptors; GABA-Benzodiazepine Receptor; GABA-Benzodiazepine Receptors; Muscimol Receptor; Muscimol Receptors; Receptors, Benzodiazepine; Receptors, Benzodiazepine-GABA; Receptors, Diazepam; Receptors, GABA-Benzodiazepine; Receptors, Muscimol; delta Subunit, GABA-A Receptor; epsilon Subunit, GABA-A Receptor; gamma-Aminobutyric Acid Subtype A Receptors
NLM Classification #: QU 60
Previous Indexing: Aminobutyric Acids (1966-1978); GABA (1979-1984); Receptors, Drug (1968-1984); Receptors, Endogenous Substances (1973-1984)
Public MeSH Note: 1994; see RECEPTORS, GABA-BENZODIAZEPINE 1985-1993; DELTA SUBUNIT, GABA-A RECEPTOR was indexed under RECEPTORS, GABA-A 2006-2010; EPSILON SUBUNIT, GABA-A RECEPTOR was indexed under RECEPTORS, GABA-A 2002-2010
History Note: 1994; was RECEPTORS, GABA-BENZODIAZEPINE 1985-1993
Entry Combination: agonists:GABA-A Receptor Agonists; antagonists & inhibitors:GABA-A Receptor Antagonists
Date Established: 1985/01/01
Date of Entry: 1984/05/31
Revision Date: 2016/07/01

Entry Combination: agonists:GABA-A Receptor Agonists; antagonists & inhibitors:GABA-A Receptor Antagonists
Allowable Qualifiers: administration & dosage (AD)

analysis (AN)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Chloride Channels [D12.776.157.530.400.175]
        
        Anoctamins [D12.776.157.530.400.175.032]
        
        Bestrophins [D12.776.157.530.400.175.063]
        
        CLC-2 Chloride Channels [D12.776.157.530.400.175.094]
        
        Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.157.530.400.175.125]
        
        Receptors, GABA-A [D12.776.157.530.400.175.562]
        
        Receptors, Glycine [D12.776.157.530.400.175.781]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Ligand-Gated Ion Channels [D12.776.157.530.400.400]
        
        Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400.100]
        
        Receptors, GABA-A [D12.776.157.530.400.400.100.100]
        
        Receptors, Glycine [D12.776.157.530.400.400.100.200]
        
        Receptors, Nicotinic [D12.776.157.530.400.400.100.500]
        
        Receptors, Serotonin, 5-HT3 [D12.776.157.530.400.400.100.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Ion Channels [D12.776.543.550.450]
        
        Chloride Channels [D12.776.543.550.450.175]
        
        Anoctamins [D12.776.543.550.450.175.032]
        
        Bestrophins [D12.776.543.550.450.175.063]
        
        CLC-2 Chloride Channels [D12.776.543.550.450.175.094]
        
        Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.543.550.450.175.125]
        
        Receptors, GABA-A [D12.776.543.550.450.175.562]
        
        Receptors, Glycine [D12.776.543.550.450.175.781]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Ion Channels [D12.776.543.550.450]
        
        Ligand-Gated Ion Channels [D12.776.543.550.450.500]
        
        Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.450.500.100]
        
        Receptors, GABA-A [D12.776.543.550.450.500.100.100]
        
        Receptors, Glycine [D12.776.543.550.450.500.100.200]
        
        Receptors, Nicotinic [D12.776.543.550.450.500.100.500]
        
        Receptors, Serotonin, 5-HT3 [D12.776.543.550.450.500.100.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Chloride Channels [D12.776.543.585.400.175]
        
        Anoctamins [D12.776.543.585.400.175.032]
        
        Bestrophins [D12.776.543.585.400.175.063]
        
        CLC-2 Chloride Channels [D12.776.543.585.400.175.094]
        
        Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.543.585.400.175.125]
        
        Receptors, GABA-A [D12.776.543.585.400.175.562]
        
        Receptors, Glycine [D12.776.543.585.400.175.781]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Ligand-Gated Ion Channels [D12.776.543.585.400.500]
        
        Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500.100]
        
        Receptors, GABA-A [D12.776.543.585.400.500.100.100]
        
        Receptors, Glycine [D12.776.543.585.400.500.100.200]
        
        Receptors, Nicotinic [D12.776.543.585.400.500.100.500]
        
        Receptors, Serotonin, 5-HT3 [D12.776.543.585.400.500.100.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.750.130]
        
        Receptors, GABA-A [D12.776.543.750.130.500]
        
        Receptors, Glycine [D12.776.543.750.130.625]
        
        Receptors, Nicotinic [D12.776.543.750.130.687]
        
        Receptors, Serotonin, 5-HT3 [D12.776.543.750.130.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Neurotransmitter [D12.776.543.750.720]
        
        Receptors, Amino Acid [D12.776.543.750.720.200]
        
        Receptors, GABA [D12.776.543.750.720.200.300]
        
        Receptors, GABA-A [D12.776.543.750.720.200.300.300]
        
        Receptors, GABA-B [D12.776.543.750.720.200.300.320]

Receptors, GABA-A Preferred

Concept UI: M0018590
Scope Note: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.
Terms: Receptors, GABA-A Preferred Term
Term UI T035448
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1985); GABA-A Receptor
Term UI T035446
Date02/22/1993
LexicalTag NON
ThesaurusID NLM (1994); GABA-A Receptors
Term UI T035447
Date02/01/1993
LexicalTag NON
ThesaurusID NLM (1994); gamma-Aminobutyric Acid Subtype A Receptors
Term UI T763914
Date01/11/2010
LexicalTag NON
ThesaurusID NLM (2011); Muscimol Receptor
Term UI T035449
Date04/16/1993
LexicalTag NON
ThesaurusID NLM (1994); Muscimol Receptors
Term UI T035450
Date05/31/1984
LexicalTag NON
ThesaurusID UNK (19XX); Receptors, Muscimol
Term UI T035451
Date05/31/1984
LexicalTag NON
ThesaurusID UNK (19XX); Benzodiazepine-GABA Receptor
Term UI T035452
Date04/16/1993
LexicalTag NON
ThesaurusID NLM (1994); GABA-Benzodiazepine Receptor
Term UI T035453
Date02/22/1993
LexicalTag NON
ThesaurusID NLM (1994); GABA-Benzodiazepine Receptors
Term UI T035454
Date04/13/1993
LexicalTag NON
ThesaurusID NLM (1994); Benzodiazepine-Gaba Receptors
Term UI T035455
Date05/05/1993
LexicalTag NON
ThesaurusID NLM (1994); Receptors, GABA-Benzodiazepine
Term UI T035456
Date02/01/1993
LexicalTag NON
ThesaurusID NLM (1994); GABA(A) Receptor
Term UI T035445
Date12/08/1987
LexicalTag NON
ThesaurusID UNK (19XX); Receptors, Benzodiazepine-GABA
Term UI T035457
Date05/31/1984
LexicalTag NON
ThesaurusID UNK (19XX)

Benzodiazepine Receptor Narrower

Concept UI: M0018591
Terms: Benzodiazepine Receptor Preferred Term
Term UI T035458
Date04/16/1993
LexicalTag NON
ThesaurusID NLM (1994); Diazepam Receptors
Term UI T035462
Date05/31/1984
LexicalTag NON
ThesaurusID UNK (19XX); Receptors, Diazepam
Term UI T035463
Date05/31/1984
LexicalTag NON
ThesaurusID UNK (19XX); Benzodiazepine Receptors
Term UI T035459
Date05/31/1984
LexicalTag NON
ThesaurusID UNK (19XX); Receptors, Benzodiazepine
Term UI T035460
Date05/31/1984
LexicalTag NON
ThesaurusID UNK (19XX); Diazepam Receptor
Term UI T035461
Date04/16/1993
LexicalTag NON
ThesaurusID NLM (1994)

GABA-A Receptor delta Subunit Narrower

GABA-A Receptor alpha Subunit Narrower

GABA-A Receptor beta Subunit Narrower

GABA-A Receptor gamma Subunit Narrower

GABA-A Receptor rho Subunit Narrower

GABA-A Receptor epsilon Subunit Narrower

Receptors, GABA-A MeSH Descriptor Data 2024