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Bestrophins MeSH Descriptor Data 2022


MeSH Heading
Bestrophins
Tree Number(s)
D12.776.157.530.400.175.063
D12.776.306.228
D12.776.543.550.450.175.063
D12.776.543.585.400.175.063
Unique ID
D000075002
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000075002
Scope Note
A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
Entry Term(s)
BEST-1 Protein
BEST-2 Protein
Bestrophin
Bestrophin Family
Bestrophin Proteins
Bestrophin-1
Bestrophin-2
Registry Number
0
Previous Indexing
Chloride Channels (1999-2017)
Eye Proteins (1999-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2021/06/30
Bestrophins Preferred
Bestrophin-1 Narrower
Bestrophin-2 Narrower
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