MeSH Browser

MeSH Heading: Genes, erbB-1
Tree Number(s): G05.360.340.024.340.375.500.791.295.300
Unique ID: D018773
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018773
Annotation: spell in titles & translations as erbB-1; GENES, ERBB-2 is also available
Scope Note: The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
Entry Term(s): EGFR Genes; Epidermal Growth Factor Receptor Genes; Genes, EGFR; Genes, erbB1; c-erbB-1 Genes; c-erbB-1 Proto-Oncogenes; erbB-1 Genes; v-erbB Genes; v-erbB Oncogenes
Previous Indexing: Oncogenes (1986-1994); Proto-Oncogenes (1985-1994)
See Also: ErbB Receptors; Oncogene Proteins v-erbB
Public MeSH Note: 1995
History Note: 1995
Date Established: 1995/01/01
Date of Entry: 1994/05/23
Revision Date: 2018/07/02

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0028104
Scope Note: The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
Terms: Genes, erbB-1 Preferred Term
Term UI T055901
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1995); erbB-1 Genes
Term UI T055900
Date04/04/1994
LexicalTag NON
ThesaurusID NLM (1995); Genes, erbB1
Term UI T373109
Date11/05/1999
LexicalTag NON
ThesaurusID NLM (2000)

Concept UI: M0028102
Terms: c-erbB-1 Genes Preferred Term
Term UI T055895
Date04/04/1994
LexicalTag NON
ThesaurusID NLM (1995); Epidermal Growth Factor Receptor Genes
Term UI T362163
Date11/05/1999
LexicalTag NON
ThesaurusID NLM (2000); EGFR Genes
Term UI T362164
Date11/05/1999
LexicalTag NON
ThesaurusID NLM (2000); c-erbB-1 Proto-Oncogenes
Term UI T055896
Date04/04/1994
LexicalTag NON
ThesaurusID NLM (1995); Genes, EGFR
Term UI T055897
Date03/01/1994
LexicalTag NON
ThesaurusID NLM (1995)

Genes, erbB-1 MeSH Descriptor Data 2024