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Genes, erbB-1 MeSH Descriptor Data 2024


MeSH Heading
Genes, erbB-1
Tree Number(s)
G05.360.340.024.340.375.500.791.295.300
Unique ID
D018773
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018773
Annotation
spell in titles & translations as erbB-1; GENES, ERBB-2 is also available
Scope Note
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
Entry Term(s)
EGFR Genes
Epidermal Growth Factor Receptor Genes
Genes, EGFR
Genes, erbB1
c-erbB-1 Genes
c-erbB-1 Proto-Oncogenes
erbB-1 Genes
v-erbB Genes
v-erbB Oncogenes
Previous Indexing
Oncogenes (1986-1994)
Proto-Oncogenes (1985-1994)
See Also
ErbB Receptors
Oncogene Proteins v-erbB
Public MeSH Note
1995
History Note
1995
Date Established
1995/01/01
Date of Entry
1994/05/23
Revision Date
2018/07/02
Genes, erbB-1 Preferred
v-erbB Genes Narrower
c-erbB-1 Genes Narrower
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