A 21-amino acid peptide that circulates in the plasma, but its source is not known. Endothelin-3 has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. It also is found throughout the gastrointestinal tract and in the lung and kidney. (N Eng J Med 1995;333(6):356-63)
Entry Term(s)
Big Endothelin 3
Big Endothelin-3
Related Numbers
129774-03-4
Previous Indexing
Endothelins (1991-1996)
Public MeSH Note
1997; see ENDOTHELINS 1991-1996; BIG ENDOTHELIN 3 was indexed under ENDOTHELINS & PROTEIN PRECURSORS 1993-2003
History Note
1997; use ENDOTHELINS 1991-1996; for BIG ENDOTHELIN 3 use ENDOTHELIN-3 (NM) 1993-2003
A 21-amino acid peptide that circulates in the plasma, but its source is not known. Endothelin-3 has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. It also is found throughout the gastrointestinal tract and in the lung and kidney. (N Eng J Med 1995;333(6):356-63)
