MeSH Browser

MeSH Heading: Paralysis, Hyperkalemic Periodic
Tree Number(s): C05.651.701.600; C10.668.491.650.600; C16.320.565.618.711.600; C18.452.648.618.711.600
Unique ID: D020513
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020513
Scope Note: An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)
Entry Term(s): Adynamia Episodica Hereditaria; Adynamia Episodica Hereditaria with or without Myotonia; Familial Hyperkalemic Periodic Paralysis; Gamstorp Disease; Gamstorp Episodic Adynamy; HyperKPP; HyperPP; Hyperkalemic Periodic Paralysis; Hyperkalemic Periodic Paralysis Type 2; Hyperkalemic Periodic Paralysis, Familial; Hyperkaliemic Periodic Paralysis Type 2; Myotonic Periodic Paralysis; Paralysis, Periodic, Hyperkalemic, Familial; Primary Hyperkalemic Periodic Paralysis; Sodium Channel Muscle Disease
Previous Indexing: Paralyses, Familial Periodic (1966-1999)
See Also: Hyperkalemia; NAV1.4 Voltage-Gated Sodium Channel
Public MeSH Note: 2000
History Note: 2000
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Musculoskeletal Diseases [C05]
- Muscular Diseases [C05.651]
  - Paralyses, Familial Periodic [C05.651.701]
    - Hypokalemic Periodic Paralysis [C05.651.701.450]
    - Paralysis, Hyperkalemic Periodic [C05.651.701.600]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
  - Muscular Diseases [C10.668.491]
    - Paralyses, Familial Periodic [C10.668.491.650]
      - Hypokalemic Periodic Paralysis [C10.668.491.650.450]
      - Paralysis, Hyperkalemic Periodic [C10.668.491.650.600]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Metal Metabolism, Inborn Errors [C16.320.565.618]
      - Paralyses, Familial Periodic [C16.320.565.618.711]
        
        Hypokalemic Periodic Paralysis [C16.320.565.618.711.550]
        
        Paralysis, Hyperkalemic Periodic [C16.320.565.618.711.600]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Metal Metabolism, Inborn Errors [C18.452.648.618]
      - Paralyses, Familial Periodic [C18.452.648.618.711]
        
        Hypokalemic Periodic Paralysis [C18.452.648.618.711.550]
        
        Paralysis, Hyperkalemic Periodic [C18.452.648.618.711.600]

Paralysis, Hyperkalemic Periodic Preferred

Concept UI: M0328224
Scope Note: An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)
Terms: Paralysis, Hyperkalemic Periodic Preferred Term
Term UI T358224
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Adynamia Episodica Hereditaria
Term UI T372447
Date10/12/1999
LexicalTag NON
ThesaurusID; Adynamia Episodica Hereditaria with or without Myotonia
Term UI T817410
Date02/06/2012
LexicalTag NON
ThesaurusID ORD (2010); Familial Hyperkalemic Periodic Paralysis
Term UI T372448
Date10/12/1999
LexicalTag NON
ThesaurusID; Gamstorp Disease
Term UI T817411
Date02/06/2012
LexicalTag EPO
ThesaurusID; Gamstorp Episodic Adynamy
Term UI T817409
Date02/06/2012
LexicalTag EPO
ThesaurusID; Hyperkalemic Periodic Paralysis
Term UI T372444
Date10/12/1999
LexicalTag NON
ThesaurusID; Hyperkalemic Periodic Paralysis, Familial
Term UI T372449
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); HyperKPP
Term UI T843490
Date05/02/2013
LexicalTag NON
ThesaurusID; HyperPP
Term UI T843491
Date05/02/2013
LexicalTag NON
ThesaurusID; Myotonic Periodic Paralysis
Term UI T372445
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Paralysis, Periodic, Hyperkalemic, Familial
Term UI T372446
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Primary Hyperkalemic Periodic Paralysis
Term UI T372450
Date10/12/1999
LexicalTag NON
ThesaurusID; Sodium Channel Muscle Disease
Term UI T817412
Date02/06/2012
LexicalTag NON
ThesaurusID ORD (2010)

Hyperkalemic Periodic Paralysis Type 2 Related

Paralysis, Hyperkalemic Periodic MeSH Descriptor Data 2024