MeSH Browser

MeSH Heading: Vascular Endothelial Growth Factor Receptor-1
Tree Number(s): D08.811.913.696.620.682.725.400.950.100; D12.776.476.568.400.950.100; D12.776.543.750.630.750.100; D12.776.543.750.750.400.910.100
Unique ID: D040281
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D040281
Scope Note: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
Entry Version: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPT 1
Entry Term(s): FLT1 RTK; FLT1 Receptor Tyrosine Kinase; Proto-Oncogene Protein flt; VEGF Receptor flt-1 Protein; VEGF Receptor, FLT; VEGFR-1; fms-Like Tyrosine Kinase
Registry Number: EC 2.7.10.1
Previous Indexing: Proto-Oncogene Proteins (1991-2002); Receptor Protein-Tyrosine Kinases (1991-2002); Receptors, Growth Factor (1993-2002)
Public MeSH Note: 2003; PROTO-ONCOGENE PROTEIN FLT (now VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1) was indexed under PROTO-ONCOGENE PROTEINS & RECEPTOR PROTEIN-TYROSINE KINASE 1991-2002
History Note: 2003; use VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (NM) 1990-2002; for FLK-1 RECEPTOR TYROSINE KINASE use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1993-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Receptors, Vascular Endothelial Growth Factor [D08.811.913.696.620.682.725.400.950]
        
        Vascular Endothelial Growth Factor Receptor-1 [D08.811.913.696.620.682.725.400.950.100]
        
        Vascular Endothelial Growth Factor Receptor-2 [D08.811.913.696.620.682.725.400.950.200]
        
        Vascular Endothelial Growth Factor Receptor-3 [D08.811.913.696.620.682.725.400.950.300]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Receptor Protein-Tyrosine Kinases [D12.776.476.568.400]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.476.568.400.950]
        
        Vascular Endothelial Growth Factor Receptor-1 [D12.776.476.568.400.950.100]
        
        Vascular Endothelial Growth Factor Receptor-2 [D12.776.476.568.400.950.200]
        
        Vascular Endothelial Growth Factor Receptor-3 [D12.776.476.568.400.950.300]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.630.750]
        
        Vascular Endothelial Growth Factor Receptor-1 [D12.776.543.750.630.750.100]
        
        Vascular Endothelial Growth Factor Receptor-2 [D12.776.543.750.630.750.200]
        
        Vascular Endothelial Growth Factor Receptor-3 [D12.776.543.750.630.750.300]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Peptide [D12.776.543.750.750]
        
        Receptors, Growth Factor [D12.776.543.750.750.400]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.750.400.910]
        
        Vascular Endothelial Growth Factor Receptor-1 [D12.776.543.750.750.400.910.100]
        
        Vascular Endothelial Growth Factor Receptor-2 [D12.776.543.750.750.400.910.200]
        
        Vascular Endothelial Growth Factor Receptor-3 [D12.776.543.750.750.400.910.300]

Vascular Endothelial Growth Factor Receptor-1 Preferred

Concept UI: M0175703
Registry Number: EC 2.7.10.1
Scope Note: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
Terms: Vascular Endothelial Growth Factor Receptor-1 Preferred Term
Term UI T490622
Date04/23/2002
LexicalTag NON
ThesaurusID NLM (2003); FLT1 Receptor Tyrosine Kinase
Term UI T205704
LexicalTag ACX
ThesaurusID NLM (2003); VEGF Receptor flt-1 Protein
Term UI T205706
LexicalTag ACX
ThesaurusID NLM (2003); VEGFR-1
Term UI T205708
LexicalTag ACR
ThesaurusID NLM (2003); fms-Like Tyrosine Kinase
Term UI T205710
LexicalTag ACX
ThesaurusID NLM (2003); Proto-Oncogene Protein flt
Term UI T205711
LexicalTag ACX
ThesaurusID NLM (2003); FLT1 RTK
Term UI T205703
LexicalTag ACR
ThesaurusID NLM (2003); VEGF Receptor, FLT
Term UI T205707
LexicalTag ACX
ThesaurusID NLM (2003)

Vascular Endothelial Growth Factor Receptor-1 MeSH Descriptor Data 2024