MeSH Browser

MeSH Heading: Mitogen-Activated Protein Kinase 14
Tree Number(s): D08.811.913.696.620.682.700.567.843.937; D12.776.476.563.567.843.937
Unique ID: D048308
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D048308
Scope Note: A 38-kDa mitogen-activated protein kinase that is abundantly expressed in a broad variety of cell types. It is involved in the regulation of cellular stress responses as well as the control of proliferation and survival of many cell types. The kinase activity of the enzyme is inhibited by the pyridinyl-imidazole compound SB 203580.
Entry Term(s): CSAID-Binding Protein; Cytokine Suppressive Anti-inflammatory Drug Binding Protein; Kinase CSBP; MAPK14; MAPK14 Mitogen-Activated Protein Kinase; MAX-Interacting Protein 2; Mxi2 Protein; SAPK2a; Stress-activated protein kinase 2a; p38alpha MAP Kinase; p38alpha Mitogen-Activated Protein Kinase; p38alphaMAPK
Registry Numbers: EC 2.7.11.24
Previous Indexing: Ca(2+)-Calmodulin Dependent Protein Kinase (1995-1999); Mitogen-Activated Protein Kinases (2000-2004)
Public MeSH Note: 2005; MITOGEN-ACTIVATED PROTEIN KINASE 14 was indexed under MITOGEN-ACTIVATED PROTEIN KINASES 2002-2004; CSAID-BINDING PROTEIN & KINASE CSBP were indexed under MITOGEN-ACTIVATED PROTEIN KINASES 2000-2004; MXI2 PROTEIN was indexed under MITOGEN-ACTIVATED PROTEIN KINASES 2000-2004, under CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1994-2000
History Note: 2005(1994)
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
        
        p38 Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567.843]
        
        Mitogen-Activated Protein Kinase 11 [D08.811.913.696.620.682.700.567.843.500]
        
        Mitogen-Activated Protein Kinase 12 [D08.811.913.696.620.682.700.567.843.750]
        
        Mitogen-Activated Protein Kinase 13 [D08.811.913.696.620.682.700.567.843.875]
        
        Mitogen-Activated Protein Kinase 14 [D08.811.913.696.620.682.700.567.843.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Mitogen-Activated Protein Kinases [D12.776.476.563.567]
        
        p38 Mitogen-Activated Protein Kinases [D12.776.476.563.567.843]
        
        Mitogen-Activated Protein Kinase 11 [D12.776.476.563.567.843.500]
        
        Mitogen-Activated Protein Kinase 12 [D12.776.476.563.567.843.750]
        
        Mitogen-Activated Protein Kinase 13 [D12.776.476.563.567.843.875]
        
        Mitogen-Activated Protein Kinase 14 [D12.776.476.563.567.843.937]

Mitogen-Activated Protein Kinase 14 Preferred

Concept UI: M0417034
Registry Numbers: EC 2.7.11.24
Scope Note: A 38-kDa mitogen-activated protein kinase that is abundantly expressed in a broad variety of cell types. It is involved in the regulation of cellular stress responses as well as the control of proliferation and survival of many cell types. The kinase activity of the enzyme is inhibited by the pyridinyl-imidazole compound SB 203580.
Terms: Mitogen-Activated Protein Kinase 14 Preferred Term
Term UI T573522
Date02/20/2004
LexicalTag NON
ThesaurusID NLM (2005); CSAID-Binding Protein
Term UI T414323
Date05/15/2000
LexicalTag ACX
ThesaurusID NLM (2005); Kinase CSBP
Term UI T414757
Date05/18/2000
LexicalTag ACX
ThesaurusID NLM (2005); p38alpha MAP Kinase
Term UI T485131
Date03/08/2002
LexicalTag NON
ThesaurusID NLM (2005); p38alphaMAPK
Term UI T485132
Date03/08/2002
LexicalTag NON
ThesaurusID NLM (2005); Cytokine Suppressive Anti-inflammatory Drug Binding Protein
Term UI T573519
Date02/20/2004
LexicalTag NON
ThesaurusID NLM (2005); MAX-Interacting Protein 2
Term UI T573568
Date02/20/2004
LexicalTag NON
ThesaurusID NLM (2005); p38alpha Mitogen-Activated Protein Kinase
Term UI T573616
Date02/20/2004
LexicalTag NON
ThesaurusID NLM (2005); Stress-activated protein kinase 2a
Term UI T573637
Date02/20/2004
LexicalTag NON
ThesaurusID NLM (2005); SAPK2a
Term UI T573638
Date02/20/2004
LexicalTag NON
ThesaurusID NLM (2005); MAPK14 Mitogen-Activated Protein Kinase
Term UI T574122
Date02/24/2004
LexicalTag NON
ThesaurusID NLM (2005); Mxi2 Protein
Term UI T264434
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); MAPK14
Term UI T573617
Date02/20/2004
LexicalTag NON
ThesaurusID NLM (2005)

Mitogen-Activated Protein Kinase 14 MeSH Descriptor Data 2025