MeSH Browser

MeSH Heading: Apolipoprotein E2
Tree Number(s): D10.532.091.500.249; D12.776.070.400.500.249; D12.776.521.120.500.249
Unique ID: D053329
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053329
Scope Note: One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
Entry Term(s): APOE-epsilon 2; APOE-epsilon2; Apo E-2; Apo E2; ApoE2; Apolipoprotein E-2; Apolipoprotein E-epsilon2
Registry Numbers: 0
Previous Indexing: Apolipoproteins E (1984-2006)
Public MeSH Note: 2007; APOLIPOPROTEIN E-2 was indexed under APOLIPOPROTEINS E 1985-2006 & under APOLIPOPROTEINS 1984
History Note: 2007 (1984)
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0119983
Registry Numbers: 0
Scope Note: One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
Terms: Apolipoprotein E2 Preferred Term
Term UI T149987
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); ApoE2
Term UI T661347
Date12/06/2005
LexicalTag NON
ThesaurusID NLM (2007); Apolipoprotein E-2
Term UI T149988
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Apolipoprotein E-epsilon2
Term UI T149986
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Apo E-2
Term UI T149984
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Apo E2
Term UI T149985
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); APOE-epsilon2
Term UI T149983
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); APOE-epsilon 2
Term UI T149982
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007)

Apolipoprotein E2 MeSH Descriptor Data 2025