MeSH Browser

MeSH Heading: Cyclic Nucleotide Phosphodiesterases, Type 5
Tree Number(s): D08.811.277.352.640.150.500; D08.811.277.352.640.155.500; D12.776.476.008.500; D12.776.476.009.500
Unique ID: D054706
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054706
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.
Entry Term(s): PDE5 Phosphodiesterases; Phosphodiesterase 5; Phosphodiesterase 5A; Phosphodiesterase 5A, cGMP-Specific; Phosphodiesterase Type 5; Phosphodiesterase Type V; Phosphodiesterase V; Phosphodiesterase-5; cGMP-Binding, cGMP-Specific 3',5'-cyclic Nucleotide Phosphodiesterase
Registry Numbers: EC 3.1.4.35
Related Numbers: EC 3.1.4.17
Public MeSH Note: 2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5 was indexed under 3',5'-CYCLIC-GMP PHOSPHODIESTERASE 1998-2007
History Note: 2008(1998)
Entry Combination: antagonists & inhibitors:Phosphodiesterase 5 Inhibitors
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Entry Combination: antagonists & inhibitors:Phosphodiesterase 5 Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Diester Hydrolases [D08.811.277.352.640]
        
        3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
        
        Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.150.100]
        
        Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.150.200]
        
        Cyclic Nucleotide Phosphodiesterases, Type 3 [D08.811.277.352.640.150.300]
        
        Cyclic Nucleotide Phosphodiesterases, Type 4 [D08.811.277.352.640.150.400]
        
        Cyclic Nucleotide Phosphodiesterases, Type 5 [D08.811.277.352.640.150.500]
        
        Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.150.600]
        
        Cyclic Nucleotide Phosphodiesterases, Type 7 [D08.811.277.352.640.150.700]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Diester Hydrolases [D08.811.277.352.640]
        
        3',5'-Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]
        
        Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.155.100]
        
        Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.155.200]
        
        Cyclic Nucleotide Phosphodiesterases, Type 5 [D08.811.277.352.640.155.500]
        
        Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.155.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - 3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - 3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]

Cyclic Nucleotide Phosphodiesterases, Type 5 Preferred

Concept UI: M0295388
Registry Numbers: EC 3.1.4.35
Related Numbers: EC 3.1.4.17
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.
Terms: Cyclic Nucleotide Phosphodiesterases, Type 5 Preferred Term
Term UI T692175
Date02/23/2007
LexicalTag NON
ThesaurusID NLM (2008); Phosphodiesterase 5A
Term UI T000896311
Date03/02/2016
LexicalTag NON
ThesaurusID NLM (2017); Phosphodiesterase Type 5
Term UI T000896312
Date03/02/2016
LexicalTag NON
ThesaurusID NLM (2017); Phosphodiesterase Type V
Term UI T000896313
Date03/02/2016
LexicalTag NON
ThesaurusID NLM (2017); Phosphodiesterase 5
Term UI T300529
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Phosphodiesterase-5
Term UI T300530
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Phosphodiesterase V
Term UI T300531
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); cGMP-Binding, cGMP-Specific 3',5'-cyclic Nucleotide Phosphodiesterase
Term UI T325393
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2008); Phosphodiesterase 5A, cGMP-Specific
Term UI T000896310
Date03/02/2016
LexicalTag ABX
ThesaurusID NLM (2017); PDE5 Phosphodiesterases
Term UI T692178
Date02/23/2007
LexicalTag ABX
ThesaurusID NLM (2008)

Cyclic Nucleotide Phosphodiesterases, Type 5 MeSH Descriptor Data 2024