MeSH Browser

MeSH Heading: Cyclic Nucleotide Phosphodiesterases, Type 6
Tree Number(s): D08.811.277.352.640.150.600; D08.811.277.352.640.155.750; D12.776.476.008.600; D12.776.476.009.750
Unique ID: D054707
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054707
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
Entry Term(s): Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit; Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit; Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit; Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit; PDE6 Phosphodiesterases; PDE6, alpha Subunit; PDE6, beta Subunit; PDE6, delta Subunit; Phosphodiesterase 6; Phosphodiesterase Type 6; Retinal Phosphodiesterase 6; Retinal Phosphodiesterase, alpha Subunit; Retinal Phosphodiesterase, beta Subunit; Retinal Phosphodiesterase, delta Subunit; Rod cGMP Phosphodiesterase, beta Subunit; alpha Subunit, PDE6; beta Subunit, PDE6; cGMP Phosphodiesterase delta Subunit; cGMP-PDE gamma Subunit; delta Subunit, PDE6; gamma Subunit, cGMP Phosphodiesterase
Registry Numbers: EC 3.1.4.35; EC 3.1.4.-; EC 3.1.4.-; EC 3.1.4.35; EC 3.1.4.35
Related Numbers: EC 3.1.4.17; EC 3.1.4.35
Public MeSH Note: 2008; PHOSPHODIESTERASE 6 (now CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6) was indexed under PHOSPHORIC ACID DIESTERASES 2001-2007; CGMP PHOSPHODIESTERASE DELTA SUBUNIT was indexed under 3,5,'-CYCLIC-GMP PHOSPHODIESTERASE 2004-2007
History Note: 2008(2001)
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Diester Hydrolases [D08.811.277.352.640]
        
        3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
        
        Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.150.100]
        
        Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.150.200]
        
        Cyclic Nucleotide Phosphodiesterases, Type 3 [D08.811.277.352.640.150.300]
        
        Cyclic Nucleotide Phosphodiesterases, Type 4 [D08.811.277.352.640.150.400]
        
        Cyclic Nucleotide Phosphodiesterases, Type 5 [D08.811.277.352.640.150.500]
        
        Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.150.600]
        
        Cyclic Nucleotide Phosphodiesterases, Type 7 [D08.811.277.352.640.150.700]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Diester Hydrolases [D08.811.277.352.640]
        
        3',5'-Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]
        
        Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.155.100]
        
        Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.155.200]
        
        Cyclic Nucleotide Phosphodiesterases, Type 5 [D08.811.277.352.640.155.500]
        
        Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.155.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - 3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - 3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]

Cyclic Nucleotide Phosphodiesterases, Type 6 Preferred

Concept UI: M0379736
Registry Numbers: EC 3.1.4.35
Related Numbers: EC 3.1.4.17; EC 3.1.4.35
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
Terms: Cyclic Nucleotide Phosphodiesterases, Type 6 Preferred Term
Term UI T692183
Date02/23/2007
LexicalTag NON
ThesaurusID NLM (2008); Retinal Phosphodiesterase 6
Term UI T437601
Date03/01/2001
LexicalTag NON
ThesaurusID NLM (2008); Phosphodiesterase 6
Term UI T601006
Date08/02/2004
LexicalTag NON
ThesaurusID NLM (2008); Phosphodiesterase Type 6
Term UI T601007
Date08/02/2004
LexicalTag NON
ThesaurusID NLM (2008); PDE6 Phosphodiesterases
Term UI T692401
Date02/27/2007
LexicalTag ABX
ThesaurusID NLM (2008)

Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit Narrower

Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit Narrower

Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit Narrower

Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit Narrower

Cyclic Nucleotide Phosphodiesterases, Type 6 MeSH Descriptor Data 2024