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Cyclic Nucleotide Phosphodiesterases, Type 6 MeSH Descriptor Data 2023


MeSH Heading
Cyclic Nucleotide Phosphodiesterases, Type 6
Tree Number(s)
D08.811.277.352.640.150.600
D08.811.277.352.640.155.750
D12.776.476.008.600
D12.776.476.009.750
Unique ID
D054707
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054707
Scope Note
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
Entry Term(s)
Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit
Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit
Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit
Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit
PDE6 Phosphodiesterases
PDE6, alpha Subunit
PDE6, beta Subunit
PDE6, delta Subunit
Phosphodiesterase 6
Phosphodiesterase Type 6
Retinal Phosphodiesterase 6
Retinal Phosphodiesterase, alpha Subunit
Retinal Phosphodiesterase, beta Subunit
Retinal Phosphodiesterase, delta Subunit
Rod cGMP Phosphodiesterase, beta Subunit
alpha Subunit, PDE6
beta Subunit, PDE6
cGMP Phosphodiesterase delta Subunit
cGMP-PDE gamma Subunit
delta Subunit, PDE6
gamma Subunit, cGMP Phosphodiesterase
Registry Number
EC 3.1.4.35
Related Numbers
EC 3.1.4.17
EC 3.1.4.35
Public MeSH Note
2008; PHOSPHODIESTERASE 6 (now CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6) was indexed under PHOSPHORIC ACID DIESTERASES 2001-2007; CGMP PHOSPHODIESTERASE DELTA SUBUNIT was indexed under 3,5,'-CYCLIC-GMP PHOSPHODIESTERASE 2004-2007
History Note
2008(2001)
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2021/05/21
Cyclic Nucleotide Phosphodiesterases, Type 6 Preferred
Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit Narrower
Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit Narrower
Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit Narrower
Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit Narrower
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