MeSH Browser

MeSH Heading: Retinoblastoma-Binding Protein 4
Tree Number(s): D05.500.781.750.500; D08.811.277.087.520.500.775; D08.811.277.087.520.750.775; D08.811.600.620.775; D08.811.600.795.775; D12.644.360.024.328.600; D12.776.157.057.158.600; D12.776.476.024.420.600; D12.776.580.219.200.500; D12.776.660.235.600.200.500; D12.776.660.769.600; D12.776.664.235.800.200.500; D12.776.930.780.890.200.500
Unique ID: D056505
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056505
Scope Note: A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2.
Entry Term(s): Chromatin Assembly Factor 1 Subunit C; Nucleosome-Remodeling Factor Subunit RBAP48; RBBP4 Protein; RbAp48 Protein; Retinoblastoma p48-Binding Protein; p48 Subunit, Chromatin Assembly Factor-1
Registry Number: 0
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2016/02/18

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]
  - Polycomb-Group Proteins [D05.500.781]
    - Polycomb Repressive Complex 2 [D05.500.781.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Amidohydrolases [D08.811.277.087]
      - Histone Deacetylases [D08.811.277.087.520]
        
        Mi-2 Nucleosome Remodeling and Deacetylase Complex [D08.811.277.087.520.500]
        
        Histone Deacetylase 1 [D08.811.277.087.520.500.100]
        
        Histone Deacetylase 2 [D08.811.277.087.520.500.200]
        
        Retinoblastoma-Binding Protein 4 [D08.811.277.087.520.500.775]
        
        Retinoblastoma-Binding Protein 7 [D08.811.277.087.520.500.887]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Amidohydrolases [D08.811.277.087]
      - Histone Deacetylases [D08.811.277.087.520]
        
        Sin3 Histone Deacetylase and Corepressor Complex [D08.811.277.087.520.750]
        
        Histone Deacetylase 1 [D08.811.277.087.520.750.100]
        
        Histone Deacetylase 2 [D08.811.277.087.520.750.200]
        
        Retinoblastoma-Binding Protein 4 [D08.811.277.087.520.750.775]
        
        Retinoblastoma-Binding Protein 7 [D08.811.277.087.520.750.887]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Multienzyme Complexes [D08.811.600]
    - Mi-2 Nucleosome Remodeling and Deacetylase Complex [D08.811.600.620]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Multienzyme Complexes [D08.811.600]
    - Sin3 Histone Deacetylase and Corepressor Complex [D08.811.600.795]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Retinoblastoma Binding Proteins [D12.644.360.024.328]
        
        E2F1 Transcription Factor [D12.644.360.024.328.049]
        
        Retinoblastoma-Binding Protein 1 [D12.644.360.024.328.100]
        
        Retinoblastoma-Binding Protein 2 [D12.644.360.024.328.200]
        
        Retinoblastoma-Binding Protein 4 [D12.644.360.024.328.600]
        
        Retinoblastoma-Binding Protein 7 [D12.644.360.024.328.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Retinoblastoma Binding Proteins [D12.776.157.057.158]
        
        E2F1 Transcription Factor [D12.776.157.057.158.049]
        
        Retinoblastoma-Binding Protein 1 [D12.776.157.057.158.100]
        
        Retinoblastoma-Binding Protein 2 [D12.776.157.057.158.200]
        
        Retinoblastoma-Binding Protein 4 [D12.776.157.057.158.600]
        
        Retinoblastoma-Binding Protein 7 [D12.776.157.057.158.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Retinoblastoma Binding Proteins [D12.776.476.024.420]
        
        E2F1 Transcription Factor [D12.776.476.024.420.049]
        
        Retinoblastoma-Binding Protein 1 [D12.776.476.024.420.100]
        
        Retinoblastoma-Binding Protein 2 [D12.776.476.024.420.200]
        
        Retinoblastoma-Binding Protein 4 [D12.776.476.024.420.600]
        
        Retinoblastoma-Binding Protein 7 [D12.776.476.024.420.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Molecular Chaperones [D12.776.580]
    - Histone Chaperones [D12.776.580.219]
      - Chromatin Assembly Factor-1 [D12.776.580.219.200]
        
        Retinoblastoma-Binding Protein 4 [D12.776.580.219.200.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nuclear Proteins [D12.776.660]
    - Chromosomal Proteins, Non-Histone [D12.776.660.235]
      - Polycomb-Group Proteins [D12.776.660.235.600]
        
        Polycomb Repressive Complex 2 [D12.776.660.235.600.200]
        
        Enhancer of Zeste Homolog 2 Protein [D12.776.660.235.600.200.250]
        
        Retinoblastoma-Binding Protein 4 [D12.776.660.235.600.200.500]
        
        Retinoblastoma-Binding Protein 7 [D12.776.660.235.600.200.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nuclear Proteins [D12.776.660]
    - Retinoblastoma Binding Proteins [D12.776.660.769]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nucleoproteins [D12.776.664]
    - Chromosomal Proteins, Non-Histone [D12.776.664.235]
      - Polycomb-Group Proteins [D12.776.664.235.800]
        
        Polycomb Repressive Complex 2 [D12.776.664.235.800.200]
        
        Enhancer of Zeste Homolog 2 Protein [D12.776.664.235.800.200.250]
        
        Retinoblastoma-Binding Protein 4 [D12.776.664.235.800.200.500]
        
        Retinoblastoma-Binding Protein 7 [D12.776.664.235.800.200.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Repressor Proteins [D12.776.930.780]
      - Polycomb-Group Proteins [D12.776.930.780.890]
        
        Polycomb Repressive Complex 2 [D12.776.930.780.890.200]
        
        Enhancer of Zeste Homolog 2 Protein [D12.776.930.780.890.200.250]
        
        Retinoblastoma-Binding Protein 4 [D12.776.930.780.890.200.500]
        
        Retinoblastoma-Binding Protein 7 [D12.776.930.780.890.200.750]

Retinoblastoma-Binding Protein 4 Preferred

Concept UI: M0527525
Registry Number: 0
Scope Note: A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2.
Terms: Retinoblastoma-Binding Protein 4 Preferred Term
Term UI T731562
Date12/11/2008
LexicalTag NON
ThesaurusID NLM (2010); Retinoblastoma p48-Binding Protein
Term UI T731585
Date12/11/2008
LexicalTag NON
ThesaurusID NLM (2010); RBBP4 Protein
Term UI T735517
Date02/23/2009
LexicalTag ABX
ThesaurusID NLM (2010); Nucleosome-Remodeling Factor Subunit RBAP48
Term UI T731587
Date12/11/2008
LexicalTag ABX
ThesaurusID NLM (2010); RbAp48 Protein
Term UI T731588
Date12/11/2008
LexicalTag ABX
ThesaurusID NLM (2010); p48 Subunit, Chromatin Assembly Factor-1
Term UI T731584
Date12/11/2008
LexicalTag NON
ThesaurusID NLM (2010); Chromatin Assembly Factor 1 Subunit C
Term UI T731586
Date12/11/2008
LexicalTag NON
ThesaurusID NLM (2010)

Retinoblastoma-Binding Protein 4 MeSH Descriptor Data 2024