Endoplasmic Reticulum-Associated Degradation MeSH Descriptor Data 2024

MeSH Heading: Endoplasmic Reticulum-Associated Degradation
Tree Number(s): G02.111.660.871.790.600.962.500; G02.111.691.600.850.500; G03.734.871.790.600.850.500; G04.434.500.500; G05.308.670.600.850.500
Unique ID: D060746
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D060746
Scope Note: A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.
Entry Term(s): ERAD Pathway
Previous Indexing: Protein Folding (1995-2011)
See Also: Endoplasmic Reticulum Stress; Proteolysis; Ubiquitination
Public MeSH Note: 2012
History Note: 2012
Date Established: 2012/01/01
Date of Entry: 2011/06/24
Revision Date: 2022/07/12

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Peptide Biosynthesis [G02.111.660]
    - Protein Biosynthesis [G02.111.660.871]
      - Protein Modification, Translational [G02.111.660.871.790]
        
        Protein Processing, Post-Translational [G02.111.660.871.790.600]
        
        Unfolded Protein Response [G02.111.660.871.790.600.962]
        
        Endoplasmic Reticulum-Associated Degradation [G02.111.660.871.790.600.962.500]

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Protein Modification, Translational [G02.111.691]
    - Protein Processing, Post-Translational [G02.111.691.600]
      - Unfolded Protein Response [G02.111.691.600.850]
        
        Endoplasmic Reticulum-Associated Degradation [G02.111.691.600.850.500]

Metabolism [G03]
- Peptide Biosynthesis [G03.734]
  - Protein Biosynthesis [G03.734.871]
    - Protein Modification, Translational [G03.734.871.790]
      - Protein Processing, Post-Translational [G03.734.871.790.600]
        
        Unfolded Protein Response [G03.734.871.790.600.850]
        
        Endoplasmic Reticulum-Associated Degradation [G03.734.871.790.600.850.500]

Cell Physiological Phenomena [G04]
- Endoplasmic Reticulum Stress [G04.434]
  - Unfolded Protein Response [G04.434.500]
    - Endoplasmic Reticulum-Associated Degradation [G04.434.500.500]

Genetic Phenomena [G05]
- Gene Expression Regulation [G05.308]
  - Protein Modification, Translational [G05.308.670]
    - Protein Processing, Post-Translational [G05.308.670.600]
      - Unfolded Protein Response [G05.308.670.600.850]
        
        Endoplasmic Reticulum-Associated Degradation [G05.308.670.600.850.500]

Endoplasmic Reticulum-Associated Degradation Preferred

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