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Unfolded Protein Response MeSH Descriptor Data 2022


MeSH Heading
Unfolded Protein Response
Tree Number(s)
G02.111.660.871.790.600.962
G02.111.691.600.850
G03.734.871.790.600.850
G05.308.670.600.850
Unique ID
D056811
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D056811
Scope Note
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
Previous Indexing
Protein Folding (1995-2009)
See Also
Endoplasmic Reticulum Stress
Endoplasmic Reticulum-Associated Degradation
Public MeSH Note
2010
History Note
2010
Date Established
2010/01/01
Date of Entry
2009/07/06
Revision Date
2016/07/01
Unfolded Protein Response Preferred
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