MeSH Browser

MeSH Heading: 2',5'-Oligoadenylate Synthetase
Tree Number(s): D08.811.913.696.445.625
Unique ID: D015088
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015088
Scope Note: An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.
Entry Term(s): (2'-5')An Polymerase; 2',5'-Oligo(A) Polymerase; 2',5'-Oligo(A) Synthetase; 2',5'-Oligoadenylate Polymerase; 2,5 Oligoadenylate Polymerase; 2,5 Oligoadenylate Synthetase; 2-5A Synthetase; ATP-(2'-5')oligo(A)adenylyltransferase
NLM Classification #: QU 141
Previous Indexing: Nucleotidyltransferases (1966-1982)
Public MeSH Note: 83
History Note: 83
Date Established: 1983/01/01
Date of Entry: 1982/05/04
Revision Date: 2016/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0023207
Scope Note: An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.
Terms: 2',5'-Oligoadenylate Synthetase Preferred Term
Term UI T044036
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1983); (2'-5')An Polymerase
Term UI T044043
Date05/04/1982
LexicalTag NON
ThesaurusID UNK (19XX); 2',5'-Oligo(A) Polymerase
Term UI T044042
Date05/04/1982
LexicalTag NON
ThesaurusID UNK (19XX); 2-5A Synthetase
Term UI T044039
Date05/04/1982
LexicalTag NON
ThesaurusID UNK (19XX); ATP-(2'-5')oligo(A)adenylyltransferase
Term UI T044040
Date05/04/1982
LexicalTag NON
ThesaurusID UNK (19XX); 2',5'-Oligo(A) Synthetase
Term UI T044041
Date05/04/1982
LexicalTag NON
ThesaurusID UNK (19XX); 2,5 Oligoadenylate Polymerase
Term UI T044037
Date07/27/1984
LexicalTag NON
ThesaurusID UNK (19XX); 2,5 Oligoadenylate Synthetase
Term UI T044035
Date05/04/1982
LexicalTag NON
ThesaurusID UNK (19XX); 2',5'-Oligoadenylate Polymerase
Term UI T044038
Date05/04/1982
LexicalTag NON
ThesaurusID UNK (19XX)

2',5'-Oligoadenylate Synthetase MeSH Descriptor Data 2024