MeSH Browser

MeSH Heading: DNA-Directed DNA Polymerase
Tree Number(s): D08.811.913.696.445.308.300
Unique ID: D004259
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004259
Annotation: general; prefer specifics
Scope Note: DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
Entry Term(s): DNA Polymerase; DNA Polymerase N3; DNA Polymerases; DNA-Dependent DNA Polymerases
Registry Numbers: EC 2.7.7.7; 0
Related Numbers: 9012-90-2
CAS Type 1 Name: Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
NLM Classification #: QU 141
Previous Indexing: DNA Nucleotidyltransferases (1968-1976)
Public MeSH Note: 98; see DNA POLYMERASES 1977-97, for DNA POLYMERASE see DNA NUCLEOTIDYLTRANSFERASES 1973-76, see DNA NUCLEOTIDYLTRANSFERASE 1968-72
History Note: 98(68); for DNA POLYMERASE use DNA NUCLEOTIDYLTRANSFERASES 1968-76
Entry Combination: antagonists & inhibitors:Nucleic Acid Synthesis Inhibitors
Date Established: 1977/01/01
Date of Entry: 1976/04/19
Revision Date: 2020/05/27

Entry Combination: antagonists & inhibitors:Nucleic Acid Synthesis Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0006665
Registry Numbers: EC 2.7.7.7
Related Numbers: 9012-90-2
Scope Note: DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
Terms: DNA-Directed DNA Polymerase Preferred Term
Term UI T012949
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1977); DNA Polymerases
Term UI T012947
Date12/04/1996
LexicalTag NON
ThesaurusID NLM (1998); DNA-Dependent DNA Polymerases
Term UI T012948
Date04/16/1976
LexicalTag NON
ThesaurusID UNK (19XX); DNA Polymerase
Term UI T000996227
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021)

DNA-Directed DNA Polymerase MeSH Descriptor Data 2024