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DNA Polymerase I MeSH Descriptor Data 2022


MeSH Heading
DNA Polymerase I
Tree Number(s)
D08.811.913.696.445.308.300.225
Unique ID
D004256
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D004256
Scope Note
A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair.
Entry Term(s)
DNA Pol I
DNA Polymerase alpha
DNA-Dependent DNA Polymerase I
Klenow Fragment
Registry Number
EC 2.7.7.7
Previous Indexing
DNA Nucleotidyltransferases (1968-1976)
Public MeSH Note
84; see DNA POLYMERASES 1977-83; for DNA POLYMERASE ALPHA see DNA POLYMERASE II 1982-97
History Note
84(77); for DNA POLYMERASE ALPHA use DNA POLYMERASE II 1982-97
Date Established
1984/01/01
Date of Entry
1976/04/21
Revision Date
2020/06/22
DNA Polymerase I Preferred
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