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A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.
Entry Term(s)
Dipeptidyl Aminopeptidase I
Dipeptidyl Peptidase I
Dipeptidyl Transferase
Registry Numbers
EC 3.4.14.1
Previous Indexing
Dipeptidyl Peptidases (1984-1999)
Public MeSH Note
2010; see DIPEPTIDYL PEPTIDASE I 2000-2009; DIPEPTIDYL PEPTIDASE I was indexed under DIPEPTIDYL PEPTIDASES 1984-1999; CATHEPSINS 1981-1984
A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.