MeSH Browser

MeSH Heading: Insulin-Like Growth Factor II
Tree Number(s): D12.644.276.742.500.003
Unique ID: D007335
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007335
Scope Note: A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.
Entry Term(s): IGF-2; IGF-II; Insulin Like Growth Factor II; Insulin-Like Somatomedin Peptide II; Multiplication-Stimulating Activity; Multiplication-Stimulating Factor; Somatomedin A; Somatomedin MSA
Registry Numbers: 67763-97-7
CAS Type 1 Name: Insulin-like growth factor II
NLM Classification #: QU 107
Previous Indexing: Blood Proteins (1966-1985); Growth Substances (1966-1985); Insulin (1966-1985); Peptides (1966-1985); Somatomedins (1973-1985); Sulfation Factor (1971-1972)
See Also: Receptor, IGF Type 1; Receptor, IGF Type 2
Public MeSH Note: 1991; see SOMATOMEDINS 1986-1990; SOMATOMEDIN A was indexed under INSULIN-LIKE GROWTH FACTOR II 1980-2004
History Note: 1991(1986)
Date Established: 1991/01/01
Date of Entry: 2024/08/09
Revision Date: 2024/06/11

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0011435
Registry Numbers: 67763-97-7
Scope Note: A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.
Terms: Insulin-Like Growth Factor II Preferred Term
Term UI T021968
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1986); IGF-2
Term UI T021973
Date04/25/1985
LexicalTag ABB
ThesaurusID UNK (19XX); IGF-II
Term UI T021966
Date04/25/1985
LexicalTag ABB
ThesaurusID UNK (19XX); Insulin Like Growth Factor II
Term UI T021967
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX); Insulin-Like Somatomedin Peptide II
Term UI T021969
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX); Multiplication-Stimulating Activity
Term UI T021970
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX); Multiplication-Stimulating Factor
Term UI T021971
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX); Somatomedin A
Term UI T101230
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); Somatomedin MSA
Term UI T021972
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX)

Insulin-Like Growth Factor II MeSH Descriptor Data 2025