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Neural Cell Adhesion Molecule L1 MeSH Descriptor Data 2025


MeSH Heading
Neural Cell Adhesion Molecule L1
Tree Number(s)
D09.400.430.890.200.250.520.578
D12.776.395.550.200.250.520.578
D12.776.543.550.200.250.520.578
D23.050.301.350.250.520.578
Unique ID
D039842
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D039842
Scope Note
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Entry Term(s)
CALL Protein
CamL1 Gene Product
Cell Adhesion Molecule L1
Cell Surface Glycoprotein L1
F11 Glycoprotein
L1 Cell Adhesion Molecule
L1CAM
NGF-Inducible Glycoprotein
NILE Glycoprotein
NILE Protein
Nerve Growth Factor-Inducible Large External Glycoprotein
Neural Adhesion Molecule L1
Registry Numbers
0
Previous Indexing
Antigens, Surface (1992-2002)
Cell Adhesion Molecules, Neuronal (1992-2002)
Membrane Glycoproteins (1992-2002)
Neural Cell Adhesion Molecules (1996-2002)
Public MeSH Note
2003; NERVE GROWTH FACTOR-INDUCIBLE LARGE EXTERNAL GLYCOPROTEIN (now NEURAL CELL ADHESION MOLECULE L1) was indexed under MEMBRANE GLYCOPROTEINS 1988-2002 & GLYCOPROTEINS 1983-1987; NEURAL CELL ADHESION MOLECULE L1; F11 GLYCOPROTEIN; CELL ADHESION MOLECULE L1; CAML1 GENE PRODUCT; CELL SURFACE GLYCOPROTEIN L1; L1 CELL ADHESION MOLECULE; L1 CAM & NEURAL ADHESION MOLECULE L1 were indexed under MEMBRANE GLYCOPROTEINS 1992-2002, NEURAL CELL ADHESION MOLECULES 1996-2002, CELL ADHESION MOLECULES, NEURONAL 1992-1995 & ANTIGENS, SURFACE 1984-1991; CALL PROTEIN was indexed under MEMBRANE GLYCOPROTEINS 1999-2002 & NEURAL CELL ADHESION MOLECULES 1999-2002; NILE PROTEIN was indexed under MEMBRANE GLYCOPROTEINS 1992-2002 & NEURAL CELL ADHESION MOLECULES 1996-2002
History Note
2003; use NEURAL CELL ADHESION MOLECULE L1 (NM) 1983-2002; for NEURAL CELL ADHESION MOLECULE L1; F11 GLYCOPROTEIN; CELL ADHESION MOLECULE L1; CAML1 GENE PRODUCT; CELL SURFACE GLYCOPROTEIN L1; L1 CELL ADHESION MOLECULE; L1 CAM & NEURAL ADHESION MOLECULE L1 use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1992-2002; for CALL PROTEIN use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1999-2002; for NILE PROTEIN use LEUCKCYTE L1 ANTIGEN COMPLEX (NM) 1996-2002
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2023/03/16
Neural Cell Adhesion Molecule L1 Preferred
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